Article

Agnarelli, Alessandro, Lauer Betran, Andrea, Papakyriakou, Athanasios, Vella, Viviana, Samuels, Mark, Papanastasopoulos, Panagiotis, Giamas, Christina, Mancini, Erika J, Stebbing, Justin, Spencer, John, Cilibrasi, Chiara, Ditsiou, Angeliki and Giamas, Georgios (2023) The inhibitory properties of a novel, selective LMTK3 kinase inhibitor. International Journal of Molecular Sciences, 24 (1). e865 1-15. ISSN 1661-6596

Hassell-Hart, Storm, Speranzini, Elisa, Srikwanjai, Sirihathai, Hossack, Euan, Roe, S Mark, Fearon, Daren, Akinbosede, Daniel, Hare, Stephen and Spencer, John (2022) Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction. Organic Letters. ISSN 1523-7060

Greenland, Barnaby, Lam, Wing T, Babra, Tahkur S, Smith, Julian H D, Bagley, Mark C, Spencer, John and Wright, Edward (2022) Synthesis and evaluation of a silver nanoparticle/polyurethane composite that exhibits antiviral activity against SARS-CoV-2. Polymers, 14 (19). a4172 1-11. ISSN 2073-4360

Panther, Lydia A, Guest, Daniel P, McGown, Andrew, Emerit, Hugo, Tareque, Raysa K, Jose, Arathy, Dadswell, Chris M, Coles, SimonJ, Tizzard, Graham J, González-Méndez, Ramon, Goodall, Charles AI, Bagley, Mark C, Spencer, John and Greenland, Barnaby W (2022) Solvent-free synthesis of core-functionalised naphthalene diimides by using a vibratory ball mill: Suzuki, Sonogashira and Buchwald–Hartwig reactions. Chemistry - A European Journal, 28 (49). e202201444 1-12. ISSN 0947-6539

McGown, Andrew, Edmonds, Anthony K, Guest, Daniel, Holmes, Verity L, Dadswell, Chris, González-Méndez, Ramón, Goodall, Charles AI, Bagley, Mark C, Greenland, Barnaby W and Spencer, John (2022) A convenient, rapid, conventional heating route to MIDA boronates. Molecules, 27 (16). pp. 1-11. ISSN 1420-3049

Spencer, John (2022) [Review] Schnider, Patrick (2021) The medicinal chemist's guide to solving ADMET challenges. ChemMedChem. a202200249. ISSN 1860-7179

Edmonds, Anthony K, Oakes, Catherine S, Hassell-Hart, Storm, Bruyère, Didier, Tizzard, Graham J, Coles, Simon J, Felix, Robert, Maple, Hannah J, Marsh, Graham P and Spencer, John (2022) Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Organic and Biomolecular Chemistry. ISSN 1477-0520

Jose, Arathy, Guest, Daniel, LeGay, Remi, Tizzard, Graham J, Coles, Simon J, Derveni, Mariliza, Wright, Edward, Marrison, Lester, Lee, Alpha A, Morris, Aaron, Robinson, Matt, Delft, Frank, Fearon, Daren, Koekemoer, Lizbé, Matviuk, Tetiana, Aimon, Anthony, Schofield, Christopher J, Malla, Tika R, London, Nir, Greenland, Barnaby W, Bagley, Mark C, Spencer, John and The Covid Moonshot Consortium, (2022) Expanding the repertoire of low‐molecular‐weight pentafluorosulfanyl‐substituted scaffolds. ChemMedChem. a202100641 1-12. ISSN 1860-7179

Neto, Brenno A D, Correra, Jose R and Spencer, John (2022) Fluorescent benzothiadiazole derivatives as fluorescence imaging dyes: a decade of a new generation probes. Chemistry: A European Journal, 28 (4). e202103262. ISSN 0947-6539

Gil-Moles, Maria, Türck, Sebastian, Basu, Uttara, Pettenuzzo, Andrea, Bhattacharya, Saurav, Rajan, Ananthu, Ma, Xiang, Büssing, Rolf, Wölker, Jessica, Burmeister, Hilke, Kusi-Nimarko, Josephine, Hassell-Hart, Storm, McGown, Andrew, Guest, Daniel, Spencer, John and others, (2021) Metallodrug profiling against SARS-CoV-2 target proteins identifies highly potent inhibitors of the S/ACE2 interaction and the papain-like protease PL^pro. Chemistry - A European Journal, 27 (71). pp. 17928-17940. ISSN 0947-6539

Devonport, Jack, Sully, Lauren, Boudalis, Athanassios K, Hassell-Hart, Storm, Leech, Matthew C, Lam, Kevin, Abdul-Sada, Alaa, Tizzard, Graham J, Coles, Simon J, Spencer, John, Vargas, Alfredo and Kostakis, George E (2021) Room temperature Cu(II) radical-triggered alkyne C-H activation. JACS Au, 1 (11). pp. 1937-1948. ISSN 2691-3704

Devonport, Jack, Bodnár, Nikolett, McGown, Andrew, Maina, Mahmoud Bukar, Serpell, Louise C, Kállay, Csilla, Spencer, John and Kostakis, George E (2021) Salpyran: a Cu(II) selective chelator with therapeutic potential. Inorganic Chemistry, 60 (20). pp. 15310-15320. ISSN 0020-1669

Rubbiani, Riccardo, Weil, Tobias, Tocci, Noemi, Mastrobuoni, Luciano, Jeger, Severin, Moretto, Marco, Ng, James, Lin, Yan, Hess, Jeannine, Ferrari, Stefano, Kaech, Andres, Young, Luke, Spencer, John, Moore, Anthony L and others, (2021) In vivo active organometallic-containing antimycotic agents. RSC Chemical Biology, 2 (4). pp. 1263-1273. ISSN 2633-0679

Devonport, Jack, Spencer, John and Kostakis, George E (2021) Breaking the symmetry: C1-salans with (N-H) backbones. Dalton Transactions. ISSN 1477-9226

Watson, Adam T, Hassell-Hart, Storm, Spencer, John and Carr, Antony M (2021) Rice (Oryza sativa) TIR1 and 5′adamantyl-IAA significantly improve the auxin-inducible degron system in Schizosaccharomyces pombe. Genes, 12 (6). a882 1-23. ISSN 2073-4425

Ansell, Melvyn B, Kostakis, George E, Navarro, Oscar and Spencer, John (2021) Synthesis of trans-mono(silyl)palladium(II) bromide complexes. Molecules, 26 (9). a2460 1-6. ISSN 1420-3049

Jose, Arathy, Tareque, Raysa Khan, Mortensen, Martin, Legay, Remi, Coles, Simon J, Tizzard, Graham J, Greenland, Barnaby W, Smart, Trevor G, Bagley, Mark C and Spencer, John (2021) Synthesis and biological evaluation of benzodiazepines containing a pentafluorosulfanyl group. Tetrahedron, 85. a132020 1-6. ISSN 0040-4020

Luparello, Claudio, Cruciata, Ilenia, Joerger, Andreas C, Ocasio, Cory A, Jones, Rhiannon, Tareque, Raysa Khan, Bagley, Mark C, Spencer, John, Walker, Martin, Austin, Carol, Ferrara, Tiziana, D′Oca, Pietro, Bellina, Rossella, Branni, Rossella and Caradonna, Fabio (2021) Genotoxicity and epigenotoxicity of carbazole-derived molecules on mcf-7 breast cancer cells. International Journal of Molecular Sciences, 22 (7). a3410 1-14. ISSN 1661-6596

Hassell-Hart, Storm, Picaud, Sarah, Lengacher, Raphael, Csucker, Joshua, Millet, Regis, Gasser, Gilles, Alberto, Roger, Maple, Hannah, Felix, Robert, Leśnikowski, Zbigniew J, Stewart, Helen J S, Chevassut, Timothy J, Morley, Simon, Filippakopoulos, Panagis and Spencer, John (2021) Probing BRD inhibition substituent effects in bulky analogues of (+)-JQ1. Helvetica Chimica Acta, 104 (3). a2000214 1-7. ISSN 0018-019X

Kaya, Ecem, Smith, David A, Smith, Claire, Morris, Lauren, Bremova-Ertl, Tatiana, Cortina-Borja, Mario, Fineran, Paul, Morten, Karl J, Poulton, Joanna, Boland, Barry, Spencer, John, Strupp, Michael and Platt, Frances M (2020) Acetyl-leucine slows disease progression in lysosomal storage disorders. Brain Communications, 3 (1). pp. 1-52. ISSN 2632-1297

Ditsiou, Angeliki, Cilibrasi, Chiara, Simigdala, Nikiana, Harris, Leanne, Vella, Viviana, Gagliano, Teresa, Iachini, Maria Chiara, Simon, Thomas, Zhou, Lihong, Hassell-Hart, Storm, Pearl, Laurence H, Roe, S Mark, Spencer, John, Prodromou, Chrisostomos, Giamas, Georgios and others, (2020) The structure-function relationship of oncogenic LMTK3. Science Advances, 6 (46). pp. 1-19. ISSN 2375-2548

Tareque, Raysa Kahn, Hassell-Hart, Storm, Krojer, Tobias, Bradley, Anthony, Velupillai, Srikannathasan, Talon, Romain, Fairhead, Michael, Day, Iain J, Bala, Kamlesh, Felix, Robert, Kemmitt, Paul, Brennan, Paul, von Delft, Frank, Díaz Sáez, Laura, Spencer, John and Huber, Kilian (2020) Deliberately losing control of C-H activation processes in the design of small molecule fragment arrays targeting peroxisomal metabolism. ChemMedChem. ISSN 1860-7179

Amer Hamzah, Harina, Rixson, Daniel, Paul-Taylor, Joseph, Doan, Huan V, Dadswell, Christopher, Roffe, Gavin W, Sridhar, Arun, Hobday, Claire L, Wedd, Charlie, Düren, Tina, Hughes, William O H, Spencer, John and Burrows, Andrew D (2020) Inclusion and release of ant alarm pheromones from metal–organic frameworks. Dalton Transactions. ISSN 1477-9226

Bauer, Matthias R, Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N, Ni, Xiaomin, Tareque, Raysa Khan, Fersht, Alan R, Spencer, John and Joerger, Andreas C (2020) Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm. ACS Chemical Biology. ISSN 1554-8929

Hassell-Hart, Storm, Runcie, Andrew, Krojer, Tobias, Doyle, Jordan, Lineham, Ella, Ocasio, Cory A, Neto, Brenno A D, Fedorov, Oleg, Marsh, Graham, Maple, Hannah, Felix, Robert, Banks, Rebecca, Ciulli, Alessio, Picaud, Sarah, Filippakopoulos, Panagis, von Delft, Frank, Brennan, Paul, Stewart, Helen J S, Chevassut, Timothy J, Walker, Martin, Austin, Carol, Morley, Simon and Spencer, John (2019) Synthesis and biological investigation of (+)-JD1, an organometallic BET bromodomain inhibitor. Organometallics. ISSN 0276-7333

Sansook, Supojjanee, Hassell-Hart, Storm, Ocasio, Cory and Spencer, John (2019) Ferrocenes in medicinal chemistry; a personal perspective. Journal of Organometallic Chemistry, 905. pp. 1-17. ISSN 0022-328X

Bauer, Matthias, Jones, Alice Rhiannon, Khan, Raysa, Springett, Bradley, Dingler, Felix, Verduci, Lorena, Patel, Ketan, Fersht, Alan, Joerger, Andreas and Spencer, John (2019) A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Medicinal Chemistry, 11 (19). pp. 2491-2504. ISSN 1756-8919

Commandeur, Daniel, Brown, Grant, Mcnulty, Peter, Dadswell, Christopher, Spencer, John and Chen, Qiao (2019) Yttrium doped ZnO nanorod arrays for increased charge mobility and carrier density for enhanced solar water splitting. The Journal of Physical Chemistry C. ISSN 1932-7455

Spencer, John, Gascon, Jose Miguel, Oliveri, Valentina, McGown, Andrew, Kaya, Ecem, Chen, yu-lin, Austin, Carol, Walker, Martin, Platt, Frances and Vecchio, Graziella (2019) Synthesis and study of novel multifunctional cyclodextrin‐deferasirox hybrids. ChemMedChem. ISSN 1860-7179

Sampani, Stavroula I, McGown, Andrew, Vargas, Alfredo, Abdul-Sada, Alaa, Tizzard, Graham J, Coles, Simon J, Spencer, John and Kostakis, George E (2019) Solvent-free synthesis and key intermediate isolation in Ni2Dy2 catalyst development in the domino ring-opening electrocyclization reaction of furfural and amines. The Journal of Organic Chemistry. ISSN 0022-3263

Neto, Brenno D, Carvalho, Pedro H P R, Correa, Jose R, Paiva, Karen, Baril, Michele, Machado, Daniel, Scholten, Jackson D, de Souza, Paulo Eduardo Narcizo, Veiga-Souza, Fabiane and Spencer, John (2019) When the strategies for cellular selectivity fail. Challenges and surprises in the design and application of fluorescent benzothiadiazole derivatives for mitochondrial staining. Organic Chemistry Frontiers. ISSN 2052-4129

Baguña Torres, Julia, Yu, Zilin, Bordoloi, Jayanta, Sunassee, Kavitha, Smith, David, Smith, Claire, Chen, Oscar, Purchase, Rupert, Tuschl, Karin, Spencer, John, Platt, Frances and Blower, Philip J (2019) Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography. BioMetals, 32 (2). pp. 293-306. ISSN 0966-0844

Lineham, Ella, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon (2019) Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/mTOR pathways on cell migration in MDA-MB-231 cells. Oncotarget, 9 (18). pp. 14148-14159. ISSN 1949-2553

Commandeur, Daniel, Brown, Grant, Hills, Edward, Spencer, John and Chen, Qiao (2019) Defect-rich ZnO nanorod arrays for efficient solar water splitting. ACS Applied Nano Materials, 2 (3). pp. 1570-1578. ISSN 2574-0970

Luparello, Claudio, Asaro, Dalia Maria Lucia, Cruciata, Ilenia, Hassell-Hart, Storm, Sansook, Supojjanee, Spencer, John and Caradonna, Fabio (2019) Cytotoxic activity of the histone deacetylase 3-Selective inhibitor Pojamide on MDA-MB-231 triple-negative breast cancer cells. International Journal of Molecular Sciences, 20 (4). 804 1-14. ISSN 1661-6596

Ocasio, Cory A., Warkentin, Alexander A, McIntyre, Patrick J, Barkovich, Krister J, Vesely, Clare, Spencer, John, Shokat, Kevan M and Bayliss, Richard (2018) Type II kinase inhibitors targeting Cys-gatekeeper kinases display orthogonality with wild type and Ala/Gly-gatekeeper kinases. ACS Chemical Biology, 13 (10). pp. 2956-2965. ISSN 1554-8929

Sansook, Supojjanee, Lineham, Ella, Hassell-Hart, Storm, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon J (2018) Probing the anticancer action of novel ferrocene analogues of MNK inhibitors. Molecules, 23 (2126). pp. 1-13. ISSN 1420-3049

Velupillai, Srikannathasan, Sáez, Laura Díaz, Krojer, Tobias, Bennett, James, Ruda, Gian Filippo, Szommer, Tamas, Straub, Verena, Nunez Alonso, Graciela, Siejka, Paulina, Bradley, Anthony, Talon, Romain, Fairhead, Michael, Elkins, Jon, London, Nir, Spencer, John, von Delft, Frank, Fedorov, Oleg, Brennan, Paul and Huber, Kilian (2018) Human peroxisomal coenzyme A diphosphatase (NUDT7): a target enabling package (TEP). Zenodo. pp. 1-15.

Ansell, Melvyn B, Furfari, Samantha K, Cloke, F Geofffrey N, Roe, S Mark, Spencer, John and Navarro, Oscar (2018) Comparison of the reactivity of the low buried-volume carbene complexes (ITMe)2Pd(PhC≡CPh) and (ITMe)2Pd(PhN=NPh). Organometallics, 37 (7). pp. 1214-1218. ISSN 0276-7333

Spencer, John and Walden, Ben (2018) Special focus: metals in medicine. Future Medicinal Chemistry, 10 (6). pp. 607-609. ISSN 1756-8919

Sansook, Supojjanee, Tuo, Wei, Bollier, Mélanie, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Fredérique, Leleu-Chavain, Natascha, Farce, Amaury, Tizzard, Graham J, Coles, Simon J, Spencer, John and Millet, Regis (2018) Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands. Future Medicinal Chemistry, 10 (6). pp. 631-638. ISSN 1756-8919

Tuo, Wei, Bollier, Mélanie, Leleu-Chavain, Natascha, Lemaire, Lucas, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Szczepanski, Fabien, Spencer, John, Chavatte, Philippe and Millet, Régis (2018) Development of novel oxazolo[5,4- d ]pyrimidines as competitive CB 2 neutral antagonists based on scaffold hopping. European Journal of Medicinal Chemistry, 146. pp. 68-78. ISSN 0223-5234

Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Tizzard, Graham J and Spencer, John (2018) N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts. Synlett, 29 (02). pp. 193-198. ISSN 0936-5214

Librizzi, Mariangela, Caradonna, Fabio, Cruciata, Ilenia, Dębski, Janusz, Supojjanee, Sansook, Dadlez, Michał, Spencer, John and Claudio, Luparello (2017) Molecular signatures associated with the treatment of triple-negative MDA-MB231 breast cancer cells with the histone deacetylase inhibitors JAHA and SAHA. Chemical Research in Toxicology, 30 (12). pp. 2187-2196. ISSN 0893-228X

Sansook, Supojjanee, Ocasio, Cory A, Day, Iain J, Tizzard, Graham J, Coles, Simon, Fedorov, Oleg, Bennett, James, Elkins, Jon and Spencer, John (2017) Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic and Biomolecular Chemistry, 40 (15). pp. 8655-8660. ISSN 1477-0520

Boonseng, Sarote, Roffe, Gavin W, Targema, Msugh, Spencer, John and Cox, Hazel (2017) Rationalization of the mechanism of in situ Pd(0) formation for cross-coupling reactions from novel unsymmetrical pincer palladacycles using DFT calculations. Journal of Organometallic Chemistry, 845. pp. 71-81. ISSN 0022-328X

Lineham, Ella, Spencer, John and Morley, Simon (2017) Dual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry, 9 (13). ISSN 1756-8919

Ocasio, Tony, Sansook, Supojjanee, Jones, Alice Rhiannon, Roberts, Justin, Scott, Thomas, Tsoureas, Nikolaos, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J, Coles, Simon J, Hochegger, Helfrid, Bradner, James E and Spencer, John (2017) Pojamide: An HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells. Organometallics, 36 (17). pp. 3276-3283. ISSN 0276-7333

Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D, Baud, Matthias G J, Ciulli, Alessio and Spencer, John (2017) Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand. ACS Omega, 2 (8). pp. 4328-4332. ISSN 2470-1343

Khan, Raysa, Boonseng, Sarote, Kemmitt, Paul, Felix, Robert, Coles, Simon J, Tizzard, Graham J, Williams, Gareth, Simmonds, Olivia, Harvey, Jessica-Lily, Atack, John, Cox, Hazel and Spencer, John (2017) Combining Sanford arylations on benzodiazepines with the nuisance effect. Advanced Synthesis and Catalysis, 359 (18). pp. 3261-3269. ISSN 1615-4150

Licona, Cynthia, Spaety, Marie-Elodie, Capuozzo, Antonella, Ali, Moussa, Santamaria, Rita, Armant, Olivier, Delalande, Francois, Van Dorsselaer, Alain, Cianferani, Sarah, Spencer, John, Pfeffer, Michel, Mellitzer, Georg and Gaiddon, Christian (2017) A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8 (2). pp. 2568-2584. ISSN 1949-2553

Ansell, Melvyn B, Navarro, Oscar and Spencer, John (2017) Transition metal catalyzed element–element′ additions to alkynes. Coordination Chemistry Reviews, 336. pp. 54-77. ISSN 0010-8545

Tuo, Wei, Leleu-Chavain, Natascha, Spencer, John, Sansook, Supojjanee, Millet, Regis and Chavatte, Philippe (2017) Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors. Journal of Medicinal Chemistry, 60 (1). pp. 4-46. ISSN 0022-2623

Ansell, Melvyn B, Kostakis, George E, Braunschweig, Holger, Navarro Fernandez, Oscar and Spencer, John (2016) Synthesis of functionalized hydrazines: facile homogeneous (n-heterocyclic carbene)-palladium(0)-catalyzed diboration and silaboration of azobenzenes. Advanced Synthesis and Catalysis, 358 (23). pp. 3765-3769. ISSN 1615-4150

Tuschl, Karin, Meyer, Esther, Valdivia, Leonardo E, Zhao, Ningning, Dadswell, Chris, Abdul-Sada, Alaa, Hung, Christina Y, Simpson, Michael A, Chong, W K, Jacques, Thomas S, Woltjer, Randy L, Eaton, Simon, Gregory, Allison, Sanford, Lynn, Kara, Eleanna, Houlden, Henry, Cuno, Stephan M, Prokisch, Holger, Valletta, Lorella, Tiranti, Valeria, Younis, Rasha, Maher, Eamonn R, Spencer, John, Straatman-Iwanowska, Ania, Gissen, Paul, Selim, Laila A M, Pintos-Morell, Guillem, Coroleu-Lletget, Wifredo, Mohammad, Shekeeb S, Yoganathan, Sangeetha, Dale, Russell C, Thomas, Maya, Rihel, Jason, Bodamer, Olaf A, Enns, Caroline A, Hayflick, Susan J, Clayton, Peter T, Mills, Philippa B, Kurian, Manju A and Wilson, Stephen W (2016) Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia. Nature Communications, 7 (1). a11601. ISSN 2041-1723

Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Ansell, Melvyn B, Menezes da Silva, Vitor H, Heerdt, Gabriel, Braga, Ataualpa A C, Spencer, John and Navarro, Oscar (2016) An experimental and theoretical study into the facile, homogenous (N-Heterocyclic Carbene)2-Pd(0) catalyzed diboration of internal and terminal alkynes. Catalysis Science and Technology, 6. pp. 7461-7467. ISSN 2044-4753

Boonseng, Sarote, Roffe, Gavin W, Jones, Rhiannon N, Tizzard, Graham J, Coles, Simon J, Spencer, John and Cox, Hazel (2016) The trans influence in unsymmetrical pincer palladacycles: an experimental and computational study. Inorganics, 4 (25). pp. 1-14. ISSN 2304-6740

Librizzi, Mariangela, Spencer, John and Luparello, Claudio (2016) Biological effect of a hybrid anticancer agent based on kinase and histone deacetylase inhibitors on triple-negative (MDA-MB231) breast cancer cells. International Journal of Molecular Sciences, 17 (8). p. 1235. ISSN 1422-0067

Close, Adam J, Kemmitt, Paul, Roe, S Mark and Spencer, John (2016) Regioselective routes to orthogonally-substituted aromatic MIDA boronates. Organic and Biomolecular Chemistry, 14 (28). pp. 6751-6756. ISSN 1477-0520

Close, Adam J, Jones, Rhiannon N, Ocasio, Cory A, Kemmitt, Paul, Roe, S Mark and Spencer, John (2016) Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors. Organic and Biomolecular Chemistry, 14. pp. 8246-8252. ISSN 1477-0520

Bauer, Matthias R, Jones, Rhiannon N, Baud, Matthias G J, Wilcken, Rainer, Boeckler, Frank M, Fersht, Alan, Joerger, Andreas C and Spencer, John (2016) Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs. ACS Chemical Biology, 11 (8). pp. 2265-2274. ISSN 1554-8929

Roffe, Gavin, Tizzard, Graham J, Coles, Simon J, Cox, Hazel and Spencer, John (2016) Synthesis of unsymmetrical NCN′ and PCN pincer palladacycles and their catalytic evaluation compared with a related SCN pincer palladacycle. Organic Chemistry Frontiers, 3 (8). pp. 957-965. ISSN 2052-4110

Spencer, John (2016) [Review] Stefan Bräse (2015) Privileged scaffolds in medicinal chemistry: design, synthesis, evaluation. ChemMedChem, 11 (10). p. 1107. ISSN 1860-7179

Roffe, Gavin W, Boonseng, Sarote, Baltus, Christine B, Coles, Simon J, Day, Iain, Jones, Rhiannon N, Press, Neil J, Ruiz, Mario, Tizzard, Graham J, Cox, Hazel and Spencer, John (2016) A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle. Royal Society Open Science, 3 (4). p. 150656. ISSN 2054-5703

Ansell, Melvyn B, Spencer, John and Navarro Fernandez, Oscar (2016) (N-heterocyclic carbene)2-Pd(0) catalyzed silaboration of internal and terminal alkynes: scope and mechanistic studies. ACS Catalysis, 6 (4). pp. 2192-2196. ISSN 2155-5435

Cox, Oakley B, Krojer, Tobias, Collins, Patrick, Monteiro, Octovia, Talon, Romain, Bradley, Anthony, Fedorov, Oleg, Amin, Jahangir, Marsden, Brian D, Spencer, John, von Delft, Frank and Brennan, Paul E (2016) A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical Science, 7 (3). pp. 2322-2330. ISSN 2041-6520

Griffiths, Kieran, Dokorou, Vassiliki N, Spencer, John, Abdul-Sada, Alaa, Vargas, Alfredo and Kostakis, George E (2016) Isoskeletal Schiff base polynuclear coordination clusters: synthetic and theoretical aspects. CrystEngComm, 18 (5). pp. 704-713. ISSN 1466-8033

Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Day, Iain J, Tizzard, Graham J and Spencer, John (2016) Late stage C―H activation of a privileged scaffold; synthesis of a library of benzodiazepines. Advanced Synthesis and Catalysis, 358 (1). pp. 98-109. ISSN 1615-4150

Sansook, Supojjanee, Tuo, Wei, Lemaire, Lucas, Tourteau, Aurélien, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Leleu-Chavain, Natascha, Tizzard, Graham J, Coles, Simon J, Millet, Régis and Spencer, John (2016) Synthesis of bioorganometallic nanomolar-potent CB2agonists containing a ferrocene unit. Organometallics, 35 (19). pp. 3361-3368. ISSN 0276-7333

Sgarlata, Carmelo, Oliveri, Valentina and Spencer, John (2015) A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution. European Journal of Inorganic Chemistry, 2015 (36). pp. 5886-5891. ISSN 1434-1948

Burrows, Andrew D, Jurcic, Monika, Mahon, Mary F, Pierrat, Sandrine, Roffe, Gavin W, Windle, Henry J and Spencer, John (2015) Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity. Dalton Transactions, 44 (31). pp. 13814-13817. ISSN 1477-9226

Owusu-Ware, Samuel K, Cherry, Anthony J, Baltus, Christine B, Spencer, John and Antonijevic, Milan D (2015) Thermal analysis of novel biphenylamide derivative. Journal of Thermal Analysis and Calorimetry, 121 (1). pp. 437-452. ISSN 1388-6150

Ansell, Melvyn B, Roberts, Debbie E, Cloke, F Geoffrey N, Navarro, Oscar and Spencer, John (2015) Synthesis of an (NHC)2Pd(SiMe3)2 (NHC = N-Heterocyclic Carbene) Complex. Catalytic, cis-Bis-Silylations of Internal Alkynes with Unactivated Disilanes. Angewandte Chemie International Edition, 54 (19). pp. 5578-5582. ISSN 1433-7851

Longo, Alessandra, Librizzi, Mariangela, Chuckowree, Irina S, Baltus, Christine B, Spencer, John and Luparello, Claudio (2015) Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells. Molecules, 20 (6). pp. 9879-9889. ISSN 1420-3049

Barbosa, Cintya, Corrêa, José R., Medeiros, Gisele A, Barreto, Gabrielle, Magalhães, Kelly G, de Oliveira, Aline L, Spencer, John, Rodrigues, Marcelo O and Neto, Brenno A D (2015) Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification. Chemistry - A European Journal, 21 (13). 5055 -5060. ISSN 0947-6539

Boonseng, Sarote, Roffe, Gavin W, Spencer, John and Cox, Hazel (2015) The nature of the bonding in symmetrical pincer palladacycles. Dalton Transactions, 44. pp. 7570-7577. ISSN 1477-9226

Chang, Pishan, Zuckermann, Alexandra M E, Williams, Sophie, Close, Adam J, Cano-Jaimez, Marife, McEvoy, James P, Spencer, John, Walker, Matthew C and Williams, Robin S B (2015) Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. Journal of Pharmacology and Experimental Therapeutics, 352 (1). pp. 43-52. ISSN 0022-3565

Joerger, Andreas C, Bauer, Matthias R, Wilcken, Rainer, Baud, Matthias G J, Harbrecht, Hannes, Exner, Thomas E, Boeckler, Frank M, Spencer, John and Fersht, Alan R (2015) Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53. Structure, 23 (12). pp. 2246-2255. ISSN 0969-2126

Spencer, John and Coaker, Hannah (2015) Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19–20 May 2015. Future Medicinal Chemistry, 7 (14). pp. 1839-1842. ISSN 1756-8919

Librizzi, Mariangela, Chiarelli, Roberto, Bosco, Liana, Sansook, Supojjanee, Gascon, Jose M, Spencer, John, Caradonna, Fabio and Luparello, Claudio (2015) The histone deacetylase inhibitor JAHA down-regulates pERK and global DNA methylation in MDA-MB231 breast cancer cells. Materials, 8 (10). pp. 7041-7047. ISSN 1996-1944

Lemaire, Lucas, Leleu-Chavain, Natascha, Tourteau, Aurélien, Abdul-Sada, Alaa, Spencer, John and Millet, Régis (2015) A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole. Tetrahedron Letters, 56 (19). pp. 2448-2450. ISSN 0040-4039

Close, Adam J, Kemmitt, Paul, Emmerson, Matthew K and Spencer, John (2014) Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates. Tetrahedron, 70 (47). pp. 9125-9131. ISSN 0040-4020

Oliveri, Valentina, Attanasio, Francesco, Puglisi, Attanasio, Spencer, John, Sgarlata, Carmelo and Vecchio, Graziella (2014) Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation. Chemistry - A European Journal, 20 (29). pp. 8954-8964. ISSN 0947-6539

Patel, Hiren, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Wang, Minghua, Zuckermann, Alexandra, Williams, Robin S B, Librizzi, Mariangela, Paranal, Ronald M, Bradner, James E and Spencer, John (2014) Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors. MedChemComm, 5. pp. 1829-1833. ISSN 2040-2503

Palmer, Rex A, Spencer, John, Mendham, Andrew P, Chowdhry, Babur Z, Lisgarten, David R, Trost, Barry M, Cramer, Nico, Male, Louise and Coles, Simon J (2014) X-ray crystallographic structure of 3-(Propan-2-ylidene) benzofuran-2(3H)-one. Journal of Pharmaceutical Chemistry, 1 (3). p. 43. ISSN 2349-5731

Tizzard, Graham J, Coles, Simon J, Edwards, Mark, Oforbike Onyeabo, Romanus, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7. pp. 182-191. ISSN 1752-153X

Oliveri, Valentina, Puglisi, Antonino, Viale, Maurizio, Aiello, Cinzia, Sgarlata, Carmelo, Vecchio, Graziella, Clarke, James, Milton, John and Spencer, John (2013) New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules. Chemistry - A European Journal, 19 (41). pp. 13946-13955. ISSN 0947-6539

Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C, Chuckowree, Irina S, Amin, Jahangir, Spencer, John and Fersht, Alan R (2013) Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Research, 41 (12). pp. 6034-6044. ISSN 0305-1048

Amin, Jahangir, Puglisi, Antonio, Clarke, James, Milton, John, Wang, Minghua, Paranal, Ronald M, Bradner, James E and Spencer, John (2013) A cyclodextrin-capped histone deacetylase inhibitor. Bioorganic and Medicinal Chemistry Letters, 23 (11). pp. 3346-3348. ISSN 0960-894X

Baltus, Christine B, Chuckowree, Irina S, Press, Neil J, Day, Iain J, Coles, Simon J, Tizzard, Graham J and Spencer, John (2013) Olefin cross-metathesis/Suzuki–Miyaura reactions on vinylphenylboronic acid pinacol esters. Tetrahedron Letters, 54 (10). pp. 1211-1217. ISSN 0040-4039

Burrows, Andrew D, Jurcic, Monika, Keenan, Luke L, Lane, Rebecca A, Mahon, Mary F, Warren, Mark R, Nowell, Harriot, Paradowski, Michael and Spencer, John (2013) Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks. Chemical Communications, 49. pp. 11260-11262. ISSN 1359-7345

Amin, Jahangir, Chuckowree, Irina, Wang, Minghua, Tizzard, Graham J, Coles, Simon J and Spencer, John (2013) Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups. Organometallics, 32 (20). pp. 5818-5825. ISSN 0276-7333

Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J, Coles, Simon J, Wang, Minghua, Bingham, John P, Hartley, John A and Spencer, John (2013) Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors. Organometallics, 32 (2). pp. 509-513. ISSN 0276-7333

Baltus, Christine B, Press, Neil J, Antonijevic, Milan D, Tizzard, Graham J, Coles, Simon J and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020

Clark, Rachel L, Clements, Carol J, Barrett, Michael P, Mackay, Simon P, Rathnam, Rajendra P, Owusu-Dapaah, George, Spencer, John and Huggan, Judith K (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of hat. Bioorganic and Medicinal Chemistry, 20 (20). pp. 6019-6033. ISSN 0968-0896

Chuckowree, Irina, Syed, Murtaza Ali, Getti, Giulia, Patel, Asha Parbhu, Garner, Hannah, Tizzard, Graham J, Coles, Simon J and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039

Librizzi, Mariangela, Longo, Alessandra, Chiarelli, Roberto, Amin, Jahanghir, Spencer, John and Luparello, Claudio (2012) Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast cancer cells. Chemical Research in Toxicology, 25 (11). pp. 2608-2611. ISSN 0893-228X

Puglisi, Antonino, Spencer, John, Oliveri, Valentina, Vecchio, Graziella, Kong, Xiaole, Clarke, James and Milton, John (2012) Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes. Dalton Transactions, 41 (10). pp. 2877-2883. ISSN 1477-9234

Spencer, John, Patel, Hiren, Deadman, John J, Palmer, Rex A, Male, Louise, Coles, Simon J, Uzoh, Oquaqa G and Price, Sarah L (2012) The unexpected but predictable tetrazole packing in flexible 1-benzyl-1H-tetrazole. CrystEngComm, 14. pp. 6441-6446. ISSN 1466-8033

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S S, Tizzard, Graham J, Coles, Simon J, Paranal, Ronald M, Bradner, James E and Heightman, Tom D (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher, Tizzard, Graham, Coles, Simon, Bingham, John, Hartley, John, Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333

Spencer, John, Casini, Angela, Zava, Olivier, Rathnam, Rajendra P, Velhanda, Santosh K, Pfeffer, Michel, Callear, Samantha K, Hursthouse, Michael B and Dyson, Paul J (2009) Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton Transactions (48). pp. 10731-10735. ISSN 1477-9234

Spencer, John, Rathnam, Rajendra P, Motukuri, Mahesh, Kotha, Arun K, Richardson, Simon C W, Hazrati, Ali, Hartley, John A, Male, Louise and Hursthouse, Michael B (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions, 38 (22). pp. 4299-4303. ISSN 1477-9226

Spencer, John, Mendham, Andrew P, Kotha, Arun K, Richardson, Simon C W, Hillard, Elizabeth A, Jaouen, Gérard, Male, Louise and Hursthouse, Michael B (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 38 (6). pp. 918-921. ISSN 1477-9226

Dupont, Jairton, Consorti, Crestina S and Spencer, John (2005) The potential of palladacycles: more than just precatalysts. Chemical Reviews, 105 (6). pp. 2527-2572. ISSN 0009-2665

Book Section

Medeiros, Gisele A, Rodrigues, Carime V, Spencer, John and Neto, Brenno AD (2022) Carbon dots (C-dots): fluorescence processes and intracellular bioimaging. In: Henini, Mohamed and Rodrigues, Marcelo Oliveira (eds.) Quantum Materials, Devices, and Applications. Elsevier. ISBN 9780128205662

Khan, Raysa and Spencer, John (2019) Palladacyclic complexes as efficient catalysts for CdH bond functionalization reactions. In: Kapdi, Anant and Maiti, Debabrata (eds.) Palladacycles. Elsevier, pp. 249-262. ISBN 9780128155059

Roffe, Gavin, Boonseng, Sarote, Cox, Hazel and Spencer, John (2018) Unsymmetrical Pincer palladacycles synthesis and reactivity. In: Morales-Morales, David (ed.) Pincer compounds: chemistry and applications. Elsevier, pp. 451-466. ISBN 9780128129319

Edited Special Journal Issue

Spencer, John and Walden, Ben, eds. (2018) Special focus: metals in medicine. Future Medicinal Chemistry, 10 (6). ISSN 1756-8919

Patent

THE UNIVERSITY OF SUSSEX [GB/GB]; Sussex House Falmer Brighton Sussex BN1 9RH (GB) (2022) Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK). .