Article

Hassell-Hart, Storm, Speranzini, Elisa, Srikwanjai, Sirihathai, Hossack, Euan, Roe, S Mark, Fearon, Daren, Akinbosede, Daniel, Hare, Stephen and Spencer, John (2022) Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction. Organic Letters. ISSN 1523-7060

Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte E L, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica J R, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances M G and Oliver, Antony W (2021) Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife, 10. a65339 1-32. ISSN 2050-084X

Ditsiou, Angeliki, Cilibrasi, Chiara, Simigdala, Nikiana, Harris, Leanne, Vella, Viviana, Gagliano, Teresa, Iachini, Maria Chiara, Simon, Thomas, Zhou, Lihong, Hassell-Hart, Storm, Pearl, Laurence H, Roe, S Mark, Spencer, John, Prodromou, Chrisostomos, Giamas, Georgios and others, (2020) The structure-function relationship of oncogenic LMTK3. Science Advances, 6 (46). pp. 1-19. ISSN 2375-2548

Cox, Brian, Zdorichenko, Victor, Paumier, Romain, Whitmarsh-Everiss, Thomas and Roe, Mark (2019) The synthesis of Waltherione F and analogues with modifications at the 2- and 3-positions as potential antitrypanosomal agents. Chemistry - A European Journal, 25 (5). pp. 1286-1292. ISSN 0947-6539

Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F, Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J Mark, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2018) Erratum to: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature Communications, 9. p. 3063. ISSN 2041-1723

Afolabi, Fatai, Souissi, Wided, Rivière, Guillaume, Lemaitre, Clement, Roe, Mark, Crickmore, Neil and Viseux, Eddy (2018) Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents. Dalton Transactions, 47 (43). pp. 15338-15343. ISSN 1477-9226

Noble, James William, Almalki, Rehab, Roe, Mark, Duman, Ramona, Wagner, Armin and Atack, John (2018) The X-ray structure of human calbindin-D28K: an improved model. Acta Crystallographica Section D: Structural Biology, 74 (10). pp. 1008-1014. ISSN 2059-7983

Kraft, L, Roe, M, Gill, R and Atack, J R (2018) Co‐crystallization of human inositol monophosphatase with the lithium mimetic L‐690,330. Acta Crystallographica Section D: Structural Biology, 74. pp. 973-978. ISSN 0907-4449

Tsoureas, Nikolaos, Cloke, Geoff, Green, Jennifer, Puschmann, Horst, Roe, Mark and Tizzard, Graham (2018) Trimerisation of carbon suboxide at a di-titanium centre to form a pyrone ring system. Chemical Science, 9 (22). pp. 5008-5014. ISSN 2041-6520

Roe, Mark, Wahab, Ben, Torok, Zsolt, Horvath, Ibolya, Vigh, Laszlo and Prodromou, Chrisostomos (2018) Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Frontiers in Molecular Biosciences, 5 (51). pp. 1-14. ISSN 2296-889X

Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F, Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J Mark, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2018) RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature Communications, 9 (1). ISSN 2041-1723

Ansell, Melvyn B, Furfari, Samantha K, Cloke, F Geofffrey N, Roe, S Mark, Spencer, John and Navarro, Oscar (2018) Comparison of the reactivity of the low buried-volume carbene complexes (ITMe)2Pd(PhC≡CPh) and (ITMe)2Pd(PhN=NPh). Organometallics, 37 (7). pp. 1214-1218. ISSN 0276-7333

Kahan, Rachel J, Farnaby, Joy H, Tsoureas, Nikolaos, Cloke, F Geoffrey N, Hitchcock, Peter B, Coles, Martyn P, Roe, S Mark and Wilson, Claire (2018) Sterically encumbered mixed sandwich compounds of uranium(III): synthesis and reactivity with small molecules. Journal of Organometallic Chemistry, 857. pp. 110-122. ISSN 0022-328X

Inman, Christopher J, Frey, Alistair S P, Kilpatrick, Alexander F R, Cloke, F Geoffrey and Roe, S Mark (2017) Carbon dioxide activation by a uranium(III) complex derived from a chelating bis(aryloxide) ligand. Organometallics, 36 (23). pp. 4539-4545. ISSN 0276-7333

Piltan, Mohammad, Farshadfar, Kaveh and Roe, S Mark (2017) Halogen bonds involved in copper(I) complexes: a study based on the electronic charge density. European Journal of Inorganic Chemistry, 2017 (20). pp. 2723-2726. ISSN 1434-1948

Gholivand, Khodayar, Kahnouji, Mohammad, Roe, S Mark, Gholami, Akram and Fadaei, Farzaneh T (2017) Palladium(II) complexes of aminothiazole-based phosphines: Synthesis, structural characterization, density functional theory calculations and catalytic application in heck reaction. Applied Organometallic Chemistry, 31 (11). e3793. ISSN 0268-2605

Blundell, Katie L I M, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2017) The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS ONE, 12 (3). e0173543. ISSN 1932-6203

Saunders, Amy J, Crossley, Ian R and Roe, S Mark (2016) Aroylphosphanes: base-free synthesis and their coordination chemistry with platinum-group metals. European Journal of Inorganic Chemistry, 2016 (25). pp. 4076-4082. ISSN 1434-1948

Gholivand, Khodayar, Farshadfar, Kaveh, Roe, S Mark, Hosseini, Mahdieh and Gholami, Akram (2016) Investigation of structure-directing interactions within copper(i)thiocyanate complexes through X-ray analyses and non-covalent interaction (NCI) theoretical approach. CrystEngComm, 18 (37). pp. 7104-7115. ISSN 1466-8033

Gholivand, Khodayar, Farshadfer, Kaveh, Roe, S Mark, Gholami, Akram and Esrafili, Mehdi D (2016) Structural and photophysical characterization of mono- and binuclear Cu(i) complexes based on carbohydrazones: a combined experimental and computational study. CrystEngComm, 18 (16). pp. 2873-2884. ISSN 1466-8033

Morgan, Rhodri M L, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2015) Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallographica Section D: Biological Crystallography, D71. pp. 1197-1206. ISSN 1399-0047

Guest, Daniel, Menezes da Silva, Victor H, de Lima Batista, Anna P, Roe, S Mark, Braga, Ataualpa A C and Navarro, Oscar (2015) (N-heterocyclic carbene)-palladate complexes in anionic Mizoroki-Heck coupling cycles: a combined experimental and computational study. Organometallics, 34 (11). pp. 2463-2470. ISSN 0276-7333

Higgins Frey, Jessica A, Cloke, F Geoffrey N and Roe, S Mark (2015) Synthesis and reactivity of a mixed-sandwich uranium(IV) primary amido complex. Organometallics, 34 (11). pp. 2102-2105. ISSN 0276-7333

Button, Zoë E, Higgins, Jessica A, Suvova, Markéta, Cloke, F Geoffrey N and Roe, S Mark (2015) Mixed sandwich thorium complexes incorporating bis(tri-isopropylsilyl)cyclooctatetraenyl and pentamethylcyclopentadienyl ligands: synthesis, structure and reactivity. Dalton Transactions, 44. pp. 2588-2596. ISSN 1477-9226

Maluenda, Irene, Chen, Ming-Tsz, Guest, Daniel, Roe, Mark, Turner, Michael L and Navarro, Oscar (2015) Room temperature, solventless telomerization of isoprene with alcohols using (N-heterocyclic carbene)–palladium catalysts. Catalysis Science and Technology, 5. pp. 1447-1451. ISSN 2044-4753

Greenacre, Victoria, Ansell, Melvyn, Roe, Mark and Crossley, Ian (2014) Synthesis, structures and coordination chemistry of singly bridged phosphane-boranes with coordinately unsaturated platinum group metals. European Journal of Inorganic Chemistry, 2014 (29). pp. 5053-5062. ISSN 1434-1948

Trathen, Nicola, Leech, Matthew C, Crossley, Ian R, Greenacre, Victoria K and Roe, S Mark (2014) Synthesis and electronic structure of the first cyaphide-alkynyl complexes. Dalton Transactions, 43 (24). pp. 9004-9007. ISSN 1477-9226

Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186

Kefalidis, Christos E, Frey, Alistair S P, Roe, S Mark, Cloke, F Geoffrey N and Maron, Laurent (2014) Formation of cyanates in low-valent uranium chemistry: a synergistic experimental/theoretical study. Dalton Transactions, 2014 (43). pp. 11202-11208. ISSN 1477-9226

Dutton, Bridie L, Kitson, Russell R A, Parry-Morris, Sarah, Roe, S Mark, Prodromou, Chrisostomos and Moody, Chrisostomos (2014) Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Organic and Biomolecular Chemistry, 12 (8). pp. 1328-1340. ISSN 1477-0520

Trathen, Nicola, Greenacre, Victoria K, Crossley, Ian R and Roe, S Mark (2013) Ambiphilic reactivity of a ruthenaphosphaalkenyl: synthesis of P‑pyrazolylphosphaalkene complexes of ruthenium(0). Organometallics, 32 (9). pp. 2501-2504. ISSN 0276-7333

Newcombe, Sonya, Bobin, Mariusz, Shrikhande, Amruta, Gallop, Chris, Pace, Yannick, Yong, Helen, Gates, Rebecca, Chaudhuri, Shuvashri, Roe, Mark, Hoffmann, Eva and Viseux, Eddy M E (2013) Gold amides as anticancer drugs: synthesis and activity studies. Organic and Biomolecular Chemistry, 19 (11). pp. 3255-3260. ISSN 1477-0520

Tsoureas, Nikolaos, Summerscales, Owen T, Cloke, F Geoffrey N and Roe, S Mark (2013) Steric effects in the reductive coupling of CO by mixed-sandwich uranium(III) complexes. Organometallics, 32 (5). pp. 1353-1362. ISSN 0276-7333

Bobin, Mariusz, Day, Iain J, Roe, Stephen M and Viseux, Eddy M E (2013) Insights into the mechanism for gold catalysis: behaviour of gold(i) amide complexes in solution. Dalton Transactions, 42 (18). pp. 6592-6602. ISSN 1477-9226

Trathen, Nicola, Greenacre, Victoria K, Crossley, Ian and Roe, Mark (2013) Ambiphilic reactivity of a ruthenaphosphaalkenyl: synthesis of P-pyrazolylphosphaalkene complexes of ruthenium(0). Organometallics, 32 (9). pp. 2501-2504. ISSN 0276-7333

Gallop, Chris W D, Bobin, Mariusz, Hourani, Petra, Dwyer, Jessica, Roe, S Mark and Viseux, Eddy (2013) Investigation of the reductive cleavage of BINAP and application to the rapid synthesis of phospholes. Journal of Organic Chemistry, 78 (13). pp. 6522-6528. ISSN 0022-3263

Sharp, Swee Y, Roe, S Mark, Kazlauskas, Egidijus, Čikotienė, Inga, Workman, Paul, Matulis, Daumantas and Prodromou, Chrisostomos (2012) Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PLoS Genetics, 7(9) (e44642). ISSN 1553-7390

Saunders, Amy J, Crossley, Ian R, Coles, Martyn P and Roe, S Mark (2012) Facile self-assembly of the first diphosphametacyclophane. Chemical Communications, 48. pp. 5766-5768. ISSN 1359-7345

Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Hayes, Angela, Raynaud, Florence I, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2011) Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. ACS Chemical Biology, 6 (12). pp. 1339-1347. ISSN 1554-8929

Millson, Stefan H, Chua, Chun-Song, Roe, S Mark, Polier, Sigrun, Solovieva, Svetlana, Pearl, Laurence H, Sim, Tiow-Suan, Prodromou, Chrisostomos and Piper, Peter W (2011) Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. FASEB Journal, 25 (11). pp. 3828-3837. ISSN 0892-6638

Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2010) Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry - A European Journal, 16 (34). pp. 10366-10372. ISSN 0947-6539

Roe, Mark, Alaoui, Hicham, Barford, David, Diogon, Marie, Kong, Eric and Zhang, Ziguo (2010) Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. Journal of Molecular Biology, 397 (5). pp. 1316-1328. ISSN 0022-2836

Roe, M, Bayliss, R, Chen, J, Leung, J, Li, K and Richards, M (2010) A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. Journal of Molecular Biology, 395 (5). pp. 908-915. ISSN 0022-2836

Roe, Mark, Barford, D, Marshall, C, Yang, J and Zhang, Z (2009) Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science, 325 (5946). pp. 1398-1402. ISSN 0036-8075

Bunney, Tom D, Opaleye, Olanivi, Roe, S Mark, Vatter, Petra, Baxendale, Rhona W, Walliser, Claudia, Everett, Katy L, Josephs, Michelle B, Christow, Carolin, Rodrigues-Lima, Fernando, Gierschik, Peter, Pearl, Laurence H and Katan, Matilda (2009) Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Molecular Cell, 34 (2). pp. 223-233. ISSN 1097-2765

Prodromou, Chrisostomos, Nuttall, James M, Millson, Stefan H, Roe, S Mark, Sim, Tiow-Suan, Tan, Doreen, Workman, Paul, Pearl, Laurence H and Piper, Peter W (2009) Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chemical Biology, 4 (4). pp. 289-297. ISSN 1554-8929

Roe, M, Barford, D, Parizotto, E, Parker, J and Wang, M (2009) Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Molecular Cell, 33 (2). pp. 204-214. ISSN 1097-2765

Roe, Mark, Odho, Zain, Southall, Stacey, Wilson, Jon and Wong, Poon-Sheng (2009) Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Molecular Cell, 33 (2). pp. 181-191. ISSN 1097-2765

Kilkenny, Mairi L, Doré, Andrew S, Roe, S Mark, Nestoras, Konstantinos, Ho, Jenny C Y, Watts, Felicity Z and Pearl, Laurence H (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signalling. Genes & Development, 22 (15). pp. 2034-47. ISSN 0890-9369

Kilkenney, M L, Dore, A, Roe, S M, Nestoras, K, Ho, J, Watts, F Z and Pearl, L (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes & Development, 22 (15). pp. 2034-2047. ISSN 0890-9369

Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S Mark, Pearl, Laurence H, Boyd, Susan M and Zhang, Ming-Qiang (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of Medicinal Chemistry, 51 (9). pp. 2853-2857. ISSN 0022-2623

Roe, Mark, Hassler, Markus, Pearl, Laurence, Thompson-Vale, Vivienne and Yue, Wyatt (2007) Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO Journal, 26 (20). pp. 4402-4412. ISSN 0261-4189

Roe, M, Barford, D, Brautigan, D, Prickett, T and Yang, J (2007) The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry, 46 (30). pp. 8807-8815. ISSN 0006-2960

Roe, Mark (2007) Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry, 46. pp. 709-719.

Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward and Workman, Paul (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research, 67 (5). pp. 2206-2216. ISSN 0008-5472

Proisy, Nicolas, Sharp, Swee Y, Boxall, Kathy, Connelly, Stephen, Roe, S Mark, Prodromou, Chrisostomos, Slawin, Alexandra M Z, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2006) Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chemistry & Biology, 13 (11). pp. 1203-1215. ISSN 1074-5521

Dore, A S, Kilkenny, M L, Jones, S A, Oliver, A W, Roe, S M, Bell, S D and Pearl, L H (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Research, 34 (16). pp. 4515-4526.

Roe, Mark, Bell, Stephen, Doré, Andrew, Sarah, Jones, Kilkenny, Mairi, Pearl, Laurence and Oliver, Antony (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Research, 34 (16). pp. 4515-4526. ISSN 0305-1048

Roe, Mark, Ish-Horowicz, David, Jennings, Barbara, Pearl, Laurence, Pickles, Laura and Wainwright, S Mark (2006) Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Molecular Cell, 22 (5). pp. 645-655. ISSN 1097-2765

Ali, Maruf M U, Roe, S Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature, 440. pp. 1013-1017. ISSN 0028-0836

Roe, Mark, Barford, D and Parker, J (2006) Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes. Cold Spring Harbour Symposium on Quantitative Biology, 71. pp. 45-50.

Roe, Mark, Bunney, Tom, Driscoll, Paul, Esposito, Diego, Gierschik, Peter, Harris, Richard, Josephs, Michelle, Katan, Matilda, Lamuño Gandarillas, Natalia, Paterson, Hugh, Pearl, Laurence, Ponting, Chris, Rodrigues-Lima, Fernando and Sorli, S Caroline (2006) Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Molecular Cell, 21 (4). pp. 495-507. ISSN 1097-2765

Zhang, Minghao, Windheim, Mark, Roe, S Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos and Pearl, Laurence H (2005) Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell, 20 (4). pp. 525-538. ISSN 1097-2765

Roe, Mark, Goodwin, G, Jones, S, Matthews, S, Pearl, L and Roe, S (2005) Crystal structure of the proximal BAH domain of the polybromo protein. Biochemistry, 389 (3). pp. 657-664.

Oliver, Antony W, Jones, Sarah A, Roe, Stephen Mark, Matthews, Steve, Goodwin, Graham H and Pearl, Laurence H (2005) Crystal structure of the proximal BAH domain of the polybromo protein. Biochemical Journal, 389 (3). pp. 657-664. ISSN 0264-6021

Cheung, Kwai-Ming J, Matthews, Thomas P, James, Karen, Rowlands, Martin G, Boxall, Katherine J, Sharp, Swee Y, Maloney, Alison, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Aherne, G Wynne, McDonald, Edward and Workman, Paul (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorganic and Medicinal Chemistry Letters, 15 (14). pp. 3338-3343. ISSN 0960-894X

Roe, Mark, Barford, David and Parker, James (2005) Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature, 434 (7033). pp. 663-666. ISSN 0028-0836

Roe, Mark (2005) Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO Journal, 24 (1). pp. 1-10. ISSN 0261-4189

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23 (6). pp. 1402-1410. ISSN 0261-4189

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23. pp. 511-519. ISSN 0261-4189

Oliver, A W, Amé, J C, Roe, S M, Good, V, de Murcia, G and Pearl, L H (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Research, 32 (2). pp. 456-464. ISSN 0305-1048

Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116 (1). pp. 87-98. ISSN 0092-8674

Meyer, Philipe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S Mark, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2003) Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Molecular Cell, 11 (3). pp. 647-658. ISSN 1097-2765

Hinks, J, Roe, Mark, Ho, J C, Watts, Felicity, Phelan, J, McAllister, M and Pearl, Laurence (2003) Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallographica Section D: Biological Crystallography, 59 (Pt 7). 1230-1233.. ISSN 0907-4449

Prodromou, Chrisostomos, Panaretou, Barry, Chohan, Shahzad, Siligardi, Giuliano, O'Brien, Ronan, Ladbury, John E, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO Journal, 19 (16). pp. 4383-92. ISSN 0261-4189

Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623

Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189

Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell, 90 (1). pp. 65-75. ISSN 0092-8674

Prodromou, Chrisostomos, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (1997) A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Structural Biology, 4 (6). pp. 477-482. ISSN 1072-8368

Conference or Workshop Item

Pal, M, Morgan, M, Phelps, S, Roe, M, Parry-Morris, S, Downs, J, Polier, S, Pearl, L and Prodromou, C (2014) Structural basis for the interaction of HSP90 with R2TP and TTT complexes. In: XXIII IUCr Congress, August 2014, Montreal, Canada.

Walliser, C, Retlich, M, Wollny, C, Harris, R, Everett, K L, Josephs, M B, Roe, S M, Vatter, P, Christow, C, Rodrigues-Lima, F, Pearl, L H, Driscoll, P C, Katan, M, Gierschik, P and Bunney, T D (2008) Rac2 regulates its effector phospholipase C-gamma 2 through interaction with a split PH domain. In: 49th Annual Meeting German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY.