Article

Hall, Belinda S, Hsieh, Louise T, Sacre, Sandra and Simmonds, Rachel E (2022) The one that got away: how macrophage-derived IL-1beta escapes the mycolactone-dependent Sec61 blockade in Buruli Ulcer. Frontiers in Immunology, 12. a788146 1-9. ISSN 1664-3224

Unterberger, Sarah, Davies, Kevin A, Rambhatla, Srinivasa Bhargav and Sacre, Sandra (2021) Contribution of toll-like receptors and the NLRP3 inflammasome in rheumatoid arthritis pathophysiology. ImmunoTargets and Therapy, 10. pp. 285-298. ISSN 2253-1556

Clanchy, Felix I L, Borghese, Federica, Bystrom, Jonas, Balog, Attilia, Penn, Henry, Hull, Dobrina N, Wells, Graham M A, Kiriakidis, Serafim, Taylor, Peter C, Sacre, Sandra M, Williams, Lynn M, Stone, Trevor W, Mageed, Rizgar A and Williams, Richard O (2021) TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis. Journal of Autoimmunity, 118. a102597 1-10. ISSN 0896-8411

Thwaites, Ryan S, Unterberger, Sarah, Chamberlain, Giselle, Gray, Henry, Jordan, Kelsey, Davies, Kevin A, Harrison, Neil A and Sacre, Sandra (2021) Expression of sterile-α and armadillo motif in rheumatoid arthritis monocytes correlates with TLR2 induced IL-1β and disease activity. Rheumatology. pp. 1-29. ISSN 1462-0324

Thwaites, Ryan S, Unterberger, Sarah, Chamberlain, Giselle, Walker-Bone, Karen, Davies, Kevin A and Sacre, Sandra (2020) TLR1/2 and 5 induce elevated cytokine levels from rheumatoid arthritis monocytes independent of ACPA or RF autoantibody status. Rheumatology. pp. 1-7. ISSN 1462-0324

Alberts, Ben, Barber, James, Sacre, Sandra, Davies, Kevin, Ghezzi, Pietro and Mullen, Lisa (2019) Precipitation of soluble uric acid is necessary for in vitro activation of the NLRP3 inflammasome in primary human monocytes. The Journal of Rheumatology, 46 (9). pp. 1141-1150. ISSN 1499-2752

Sacre, Sandra, Jaxa-Chamiec, Albert, Low, Caroline, Chamberlain, Giselle and Tralau-Stewart, Cathy (2019) Structural modification of the antidepressant mianserin suggests that its anti-inflammatory activity may be independent of 5-Hydroxytryptamine receptors. Frontiers in Immunology, 10 (1167). pp. 1-9. ISSN 1664-3224

Ingram, Sonia, Mengozzi, Manuela, Sacre, Sandra, Mullen, Lisa and Ghezzi, Pietro (2019) Differential induction of nuclear factor-like 2 signature genes with toll-like receptors stimulation. Free Radical Biology and Medicine, 135. pp. 245-250. ISSN 0891-5849

Alberts, Ben M, Sacre, Sandra M, Bush, Peter G and Mullen, Lisa M (2019) Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation. Journal of Cellular and Molecular Medicine, 23 (2). pp. 1617-1621. ISSN 1582-1838

Jenkins, Valerie, Thwaites, Ryan, Cercignani, Mara, Sacre, Sandra, Harrison, Neil, Whiteley-Jones, Hefina, Mullen, Lisa, Chamberlain, Giselle, Davies, Kevin, Zammit, Charles, Matthews, Lucy and Harder, Helena (2016) A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’ in breast cancer patients. SpringerPlus, 5 (1). a390. ISSN 2193-1801

Sacre, Sandra, Lo, Alexandra, Gregory, Bernard, Stephens, Matthew, Chamberlain, Giselle, Stott, Philip and Brennan, Fionula (2016) Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model. European Journal of Immunology, 46 (3). pp. 772-81. ISSN 1521-4141

Davies, K A, Thwaites, R, Emery, P, Ponchel, F and Sacre, S (2015) AB0176 increased toll-like receptor 5 signalling and IL-6 production in monocytes from patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 74 (2). a949. ISSN 0003-4967

Bryant, Clare E, Gay, Nick J, Heymans, Stephane, Sacre, Sandra, Schaefer, Liliana and Midwood, Kim S (2015) Advances in Toll-like receptor biology: modes of activation by diverse stimuli. Critical Reviews in Biochemistry and Molecular Biology, 50 (5). pp. 359-379. ISSN 1040-9238

Mullen, Lisa, Ferdjani, Jason and Sacre, Sandra (2015) Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures. Molecular Medicine, 21 (1). pp. 726-734. ISSN 1528-3658

Mullen, Lisa M, Chamberlain, Giselle and Sacre, Sandra (2015) Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease. Arthritis Research & Therapy, 17 (1). p. 122. ISSN 1478-6362

Thwaites, Ryan, Chamberlain, Giselle and Sacre, Sandra (2014) Emerging role of endosomal toll-like receptors in rheumatoid arthritis. Frontiers in Immunology, 5. pp. 1-8. ISSN 1664-3224

Cervellini, I, Sacre, S, Ghezzi, P and Mengozzi, M (2013) Erythropoietin does not affect TNF and IL-6 production directly. Journal of Biological Regulators & Homeostatic Agents, 27 (1). pp. 189-196. ISSN 0393-974X

Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Williams, Richard and Sacre, Sandra (2012) Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. Arthritis Research & Therapy, 14 (3). R142. ISSN 1478-6362

Clanchy, Felix I.L. and Sacre, Sandra M. (2010) Modulation of toll-like receptor function has therapeutic potential in autoimmune disease. Expert Opinion on Biological Therapy, 10 (12). pp. 1703-1716. ISSN 1471-2598

Sacre, Sandra M., Medghalchi, Mino, Gregory, Bernard, Brennan, Fionula and Williams, Richard (2010) Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Athritis and Rheumatism, 62 (3). pp. 683-693. ISSN 0004-3591

Midwood, K.S., Piccinini, A.M. and Sacre, Sandra M. (2009) Targeting Toll-like Receptors in Autoimmunity. Current Drug Targets, 10 (11). pp. 1139-1155. ISSN 1389-4501

Midwood, Kim, Sacre, Sandra, Piccinini, Anna M, Inglis, Julia, Trebaul, Annette, Chan, Emma, Drexler, Stefan, Sofat, Nidhi, Kashiwagi, Masahide, Orend, Gertraud, Brennan, Fionula and Foxwell, Brian (2009) Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nature Medicine, 15 (7). pp. 774-80. ISSN 1078-8956

Turner, J J O, Smolinska, M J, Sacre, S M and Foxwell, B M J (2009) Induction of TLR tolerance in human macrophages by adiponectin: does LPS play a role? Scandinavian Journal of Immunology, 69 (4). pp. 329-336. ISSN 1365-3083

Sacre, Sandra M, Lo, Alexandra, Gregory, Bernard, Simmonds, Rachel E, Williams, Lynn, Feldmann, Marc, Brennan, Fionula M and Foxwell, Brian M (2008) Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. Journal of Immunology, 181 (11). pp. 8002-8009. ISSN 0022-1767

Lundberg, Anna M, Drexler, Stefan K, Monaco, Claudia, Williams, Lynn M, Sacre, Sandra M, Feldmann, Marc and Foxwell, Brian M (2007) Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood, 110 (9). pp. 3245-3252. ISSN 0006-4971

Sacre, Sandra M, Drexler, Stefan K, Andreakos, Evangelos, Feldmann, Marc, Brennan, Fionula M and Foxwell, Brian M J (2007) Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue. Annals of the Rheumatic Diseases, 66 Sup. iii81-iii86. ISSN 0003-4967

Sacre, Sandra M, Lundberg, Anna M C, Andreakos, Evangelos, Taylor, Corinne, Feldmann, Marc and Foxwell, Brian M (2007) Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling. Journal of Immunology, 178 (4). pp. 2148-2154. ISSN 0022-1767

Sacre, Sandra M, Andreakos, Evangelos, Kiriakidis, Serafim, Amjadi, Parisa, Lundberg, Anna, Giddins, Grey, Feldmann, Marc, Brennan, Fionula and Foxwell, Brian M (2007) The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. American Journal of Pathology, 170 (2). pp. 518-525. ISSN 0002-9440

Drexler, Stefan K, Sacre, Sandra M and Foxwell, Brian M (2006) Toll-like receptors: a new target in rheumatoid arthritis? Expert Review of Clinical Immunology, 2 (4). pp. 585-599. ISSN 1744-8409

Andreakos, Evangelos, Sacre, Sandra, Foxwell, Brian M and Feldmann, Marc (2005) The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Frontiers in Biosciences, 10. pp. 2478-88. ISSN 1093-4715

Sacre, Sandra M, Andreakos, Evangelos, Taylor, Peter, Feldmann, Marc and Foxwell, Brian M (2005) Molecular therapeutic targets in rheumatoid arthritis. Expert Reviews in Molecular Medicine, 7 (16). pp. 1-20. ISSN 1462-3994

Sacre, Sandra M, Andreakos, Evangelos, Feldmann, Mark and Foxwell, Brian M (2004) Endotoxin signaling in human macrophages: signaling via an alternate mechanism. Journal of Endotoxin Research, 10 (6). pp. 445-452. ISSN 0968-0519

Andreakos, Evangelos, Sacre, Sandra M, Smith, Clive, Lundberg, Anna, Kiriakidis, Serafim, Stonehouse, Tim, Monaco, Claudia, Feldmann, Marc and Foxwell, Brian M (2004) Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood, 103 (6). pp. 2229-2237. ISSN 0006-4971

Sacre, Sandra M, Stannard, Anita K and Owen, James S (2003) Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells. FEBS Letters, 540 (1-3). pp. 181-187. ISSN 0014-5793

Feldmann, M, Andreakos, E, Smith, C, Bondeson, J, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, Sandra, Lundberg, A, Paleolog, E, Horwood, N J, Brennan, F M and Foxwell, B M J (2002) Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases, 61 Sup. ii13-ii18. ISSN 0003-4967

Sacre, Sandra M and Moss, Stephen E (2002) Intracellular localization of endothelial cell annexins is differentially regulated by oxidative stress. Experimental Cell Research, 274 (2). pp. 254-263. ISSN 0014-4827

Kubista, Helmut, Sacre, Sandra and Moss, Stephen (2002) Annexins and membrane fusion. Subcellular Biochemistry, 34. pp. 73-131. ISSN 0306-0225

Stannard, A K, Riddell, D R, Sacre, S M, Tagalakis, A D, Langer, C, von Eckardstein, A, Cullen, P, Athanasopoulos, T, Dickson, G and Owen, J S (2001) Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. Journal of Biological Chemistry, 276 (49). pp. 46011-46016. ISSN 0021-9258