Article

Benstead-Hume, Graeme, Wooller, Sarah, Downs, Jessica and Pearl, Frances (2019) Defining signatures of arm-wise copy number change and their associated drivers in kidney cancers. International Journal of Molecular Sciences, 20 (22). a5762. ISSN 1661-6596

Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzi, Lane, Karen A, Downs, Jessica and Pearl, Frances M G (2019) Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. PLoS Computational Biology, 15 (4). e1006888. ISSN 1553-7358

Meisenberg, Cornelia, Pinder, Sarah I, Hopkins, Suzanna R, Wooller, Sarah K, Benstead-Hume, Graeme, Pearl, Frances M G, Jeggo, Penny A and Downs, Jessica A (2019) Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability. Molecular Cell, 73 (2). 212-223.e7. ISSN 1097-2765

Jeggo, Penny A, Downs, Jessica A and Gasser, Susan M (2017) Chromatin modifiers and remodellers in DNA repair and signalling. Philosophical Transactions B: Biological Sciences, 372 (1731). pp. 1-6. ISSN 0962–8436

Myrianthopoulos, Vassilios, Gaboriaud-Kolar, Nicolas, Tallant, Cynthia, Hall, Michelle-Lynn, Grigoriou, Stylianos, Brownlee, Peter Moore, Fedorov, Oleg, Rogers, Catherine, Heidenreich, David, Wanior, Marek, Drosos, Nikolaos, Mexia, Nikitia, Savitsky, Pavel, Bagratuni, Tina, Kastritis, Efstathios, Terpos, Evangelos, Filippakopoulos, Panagis, Müller, Susanne, Skaltsounis, Alexios-Leandros, Downs, Jessica Ann, Knapp, Stefan and Mikros, Emmanuel (2016) Discovery and optimization of a selective ligand for the switch/sucrose nonfermenting-related bromodomains of polybromo protein-1 by the use of virtual screening and hydration analysis. Journal of Medicinal Chemistry, 59 (19). pp. 8787-8803. ISSN 0022-2623

Hopkins, Suzanna R, McGregor, Grant A, Murray, Johanne M, Downs, Jessica A and Savic, Velibor (2016) Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. DNA Repair, 46. pp. 47-54. ISSN 1568-7864

Schalbetter, Stephanie A, Mansoubi, Sahar, Chambers, Anna L, Downs, Jessica A and Baxter, Jonathan (2015) Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the National Academy of Sciences, 112 (33). E4565-E4570. ISSN 0027-8424

Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna, Riballo, Queti, Herbert, Alex, Kunzel, Julia, Lobrich, Markus, Jeggo, Penny and Downs, Jessica (2014) Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell, 55 (5). pp. 723-732. ISSN 1097-2765

Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186

Brownlee, Peter M, Chambers, Anna L, Cloney, Ross, Bianchi, Alessandro and Downs, Jessica A (2014) BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell Reports, 6 (6). pp. 973-981. ISSN 2211-1247

Chambers, Anna L, Pearl, Laurence H, Oliver, Antony W and Downs, Jessica A (2013) The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Research, 41 (19). pp. 9168-9182. ISSN 0305-1048

Chambers, Anna L, Ormerod, Georgina, Durley, Samual C, Sing, Tina L, Brown, Grant W, Kent, Nicholas A and Downs, Jessica A (2012) The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes & Development, 26 (23). pp. 2590-2603. ISSN 0890-9369

Niimi, Atsuko, Chambers, Anna L, Downs, Jessica A and Lehmann, Alan R (2012) A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Research, 40 (15). pp. 7393-7403. ISSN 0305-1048

Brownlee, Peter M, Chambers, Anna L, Oliver, Antony W and Downs, Jessica A (2012) Cancer and the bromodomains of BAF180. Biochemical Society Transactions, 40 (2). pp. 364-369. ISSN 0300-5127

Chambers, Anna L and Downs, Jessica A (2012) The RSC and INO80 chromatin-remodeling complexes in DNA double-strand break repair. Progress in molecular biology and translational science, 110. pp. 229-261. ISSN 1878-0814

Chambers, A L, Brownlee, P M, Durley, S C, Beacham, T, Kent, N A and Downs, J A (2012) The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. PLoS ONE, 7 (2). e32016. ISSN 1932-6203

Foster, Elinor R and Downs, Jessica A (2009) Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. Journal of Cell Biology, 184 (5). pp. 631-638. ISSN 0021-9525

Titman, Christopher M, Downs, Jessica A, Oliver, Stephen G, Carmichael, Paul L, Scott, Andrew D and Griffin, Julian L (2009) A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae. Molecular BioSystems, 5 (12). pp. 1913-1924. ISSN 1742-206X

Downs, Jessica (2008) Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. DNA Repair, 7 (12). pp. 2020-2024. ISSN 1568-7864

Bilsland, Elizabeth, Hult, Malin, Bell, Stephen D, Sunnerhagen, Per and Downs, Jessica A (2007) The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage. DNA Repair, 6 (10). pp. 1471-1484. ISSN 1568-7864

Kent, Nicholas A, Chambers, Anna L and Downs, Jessica A (2007) Dual Chromatin Remodeling Roles for RSC during DNA Double Strand Break Induction and Repair at the Yeast MAT Locus. Journal of Biological Chemistry, 282 (38). pp. 27693-27701. ISSN 0021-9258

Harvey, Anne C, Jackson, Stephen P and Downs, Jessica A (2005) Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair. Genetics, 170. pp. 543-553. ISSN 0016-6731

Downs, Jessica A, Allard, Stéphane, Jobin-Robitaille, Olivier, Javaheri, Ali, Auger, Andréanne, Bouchard, Nathalie, Kron, Stephen J, Jackson, Stephen P and Côté, Jacques (2004) Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Molecular Cell, 16 (6). pp. 979-990. ISSN 1097-2765

Downs, Jessica A, Kosmidou, Effie, Morgan, Alan and Jackson, Stephen P (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Molecular Cell, 11 (6). pp. 1685-1692. ISSN 1097-2765

Buratowski, Robin M, Downs, Jessica and Buratowski, Stephen (2002) Interdependent interactions between TFIIB, TATA binding protein, and DNA. Molecular and Cellular Biology, 22 (24). pp. 8735-8743. ISSN 0270-7306

Conference or Workshop Item

Pal, M, Morgan, M, Phelps, S, Roe, M, Parry-Morris, S, Downs, J, Polier, S, Pearl, L and Prodromou, C (2014) Structural basis for the interaction of HSP90 with R2TP and TTT complexes. In: XXIII IUCr Congress, August 2014, Montreal, Canada.