Article

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Sian R, Goodyear, Richard J, Derudas, Marco, Cantillon, Daire, Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N, Osgood, Richard T, Wilson, Charlotte Donald, Bull, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corne J and Richardson, Guy P (2021) Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI Insight, 6 (7). a145704 1-22. ISSN 2379-3708

O'Reilly, Molly, Kirkwood, Nerissa K, Kenyon, Emma J, Huckvale, Rosemary, Cantillon, Daire M, Waddell, Simon J, Ward, Simon E, Richardson, Guy P, Kros, Corné J and Derudas, Marco (2019) Design, synthesis and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry, 62 (11). pp. 5312-5329. ISSN 0022-2623

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bulley, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. Journal of Clinical Investigation Insight, 2 (24). a96773 1-16. ISSN 2379-3708

Derudas, Marco, Vanpouille, Christophe, Carta, Davide, Zicari, Sonia, Andrei, Graciela, Snoeck, Robert, Brancale, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher (2017) Virtual Screening of acyclovir derivatives as potential antiviral agents: design, synthesis, and biological evaluation of new acyclic nucleoside ProTides. Journal of Medicinal Chemistry, 60 (18). pp. 7876-7896. ISSN 0022-2623

Kirkwood, Nerissa K, O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J, Huckvale, Rosemary, van Netten, Sietse M, Ward, Simon E, Richardson, Guy P and Kros, Corné Kros (2017) d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

McGuigan, Christopher, Serpi, Michaela, Slusarczyk, Magdalena, Ferrari, Valentina, Pertusati, Fabrizio, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim (2016) Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen, 2016 (5). pp. 227-235. ISSN 2191-1363

McGuigan, Christopher, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar, Pertusati, Fabrizio, Serpi, Michaela, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D, Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios and Bhakta, Sanjib (2014) ProTides of N-(3-(5-(2′-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorganic and Medicinal Chemistry, 22 (9). pp. 2816-2824. ISSN 0968-0896

Toti, Kiran S, Derudas, Marco, Pertusati, Fabrizio, Sinnaeve, Davy, Van den Broeck, Freya, Margamuljana, Lia, Martins, José C, Herdewijn, Piet, Balzarini, Jan, McGuigan, Christopher and Van Calenbergh, Serge (2014) Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity. The Journal of Organic Chemistry, 79 (11). pp. 5097-5112. ISSN 0022-3263

McGuigan, Christopher, Bourdin, Claire, Derudas, Marco, Hamon, Nadège, Hinsinger, Karen, Kandil, Sahar, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio, Serpi, Michaela, Slusarczyk, Magdalena, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan (2013) Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry, 70. pp. 326-340. ISSN 0223-5234

Vanpouille, Christophe, Lisco, Andrea, Introini, Andrea, Grivel, Jean-Charles, Munawwar, Arshi, Merbah, Melanie, Schinazi, Raymond F, Derudas, Marco, McGuigan, Christopher, Balzarini, Jan and Margolis, Leonid (2012) Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Antimicrobial Agents and Chemotherapy, 56 (5). pp. 2604-2611. ISSN 0066-4804

Derudas, Marco and McGuigan, Christopher (2012) Serendipity and VZV drug discovery. Drug Discovery Today: Technologies, 9 (3). e177-e181. ISSN 1740-6749

Derudas, Marco, Pala, Nicolino, Sanna, Vanna, Dallocchio, Roberto, Dessì, Alessandro, Roggio, Anna Maria and Sechi, Mario (2011) Design and synthesis of novel polycycles based on the 3H-pyrrolo/6,7-dihydropyrido[1,2-a]indole scaffold as templates for pharmaceutical development. Journal of Heterocyclic Chemistry, 48 (5). pp. 1161-1168. ISSN 0022-152X

Toti, Kiran S, Derudas, Marco, McGuigan, Christopher, Balzarini, Jan and Van Calenbergh, Serge (2011) Synthesis and antiviral evaluation of α-l-2′-deoxythreofuranosyl nucleosides. European Journal of Medicinal Chemistry, 46 (9). pp. 3704-3713. ISSN 0223-5234

Gomaa, Mohamed F Y, Pala, Nicolino, Derudas, Marco, Hasanen, Jehan Abd-Elrazik, El-Tamany, El-Sayed H, Casule, Paola, Mariani, Alberto and Sechi, Mario (2011) Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors. Arkivoc, 2011 (9). pp. 1-14. ISSN 1551-7012

Derudas, Marco, Brancale, Andrea, Naesens, Lieve, Neyts, Johan, Balzarini, Jan and McGuigan, Christopher (2010) Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin. Bioorganic and Medicinal Chemistry, 18 (7). pp. 2748-2755. ISSN 0968-0896

Derudas, Marco, Quintiliani, Maurizio, Brancale, Andrea, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan and McGuigan, Christopher (2010) Evaluation of novel phosphoramidate ProTides of the 2′-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue. Antiviral Chemistry and Chemotherapy, 21 (1). pp. 15-31. ISSN 2040-2066

Vanpouille, Christophe, Lisco, Andrea, Derudas, Marco, Saba, Elisa, Grivel, Jean‐Charles, Brichacek, Beda, Scrimieri, Francesca, Schinazi, Raymond, Schols, Dominique, McGuigan, Christopher, Balzarini, Jan and Margolis, Leonid (2010) A new class of dual‐targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both Human Immunodeficiency Virus Type 1 and Herpes Simplex Virus Type 2. Journal of Infectious Diseases, 201 (4). pp. 635-643. ISSN 0022-1899

McGuigan, Christopher, Derudas, Marco, Quintiliani, Maurizio, Andrei, Graciela, Snoeck, Robert, Henson, Geoffrey and Balzarini, Jan (2009) 2′-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743. Bioorganic and Medicinal Chemistry Letters, 19 (22). pp. 6264-6267. ISSN 0960-894X

McGuigan, Christopher, Bidet, Olivier, Derudas, Marco, Andrei, Graciela, Snoeck, Robert and Balzarini, Jan (2009) Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus. Bioorganic and Medicinal Chemistry, 17 (8). pp. 3025-3027. ISSN 0968-0896

Sechi, Mario, Derudas, Marco, Dallocchio, Roberto, Dessì, Alessandro, Cosseddu, Alessia and Paglietti, Giuseppe (2009) DNA Binders: 1. Evaluation of DNA-Interactive Ability, Design, and Synthesis of Novel Intercalating Agents. Letters in Drug Design and Discovery, 6 (1). pp. 56-62. ISSN 1570-1808

Tchesnokov, Egor P, Obikhod, Aleksandr, Massud, Ivana, Lisco, Andrea, Vanpouille, Christophe, Brichacek, Beda, Balzarini, Jan, McGuigan, Christopher, Derudas, Marco, Margolis, Leonid, Schinazi, Raymond F and Götte, Matthias (2009) Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. Journal of Biological Chemistry, 284 (32). pp. 21496-21504. ISSN 0021-9258

Derudas, Marco, Carta, Davide, Brancale, Andrea, Vanpouille, Christophe, Lisco, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher (2009) The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. Journal of Medicinal Chemistry, 52 (17). pp. 5520-5530. ISSN 0022-2623

Lisco, Andrea, Vanpouille, Christophe, Tchesnokov, Egor P, Grivel, Jean-Charles, Biancotto, Angélique, Brichacek, Beda, Elliott, Julie, Fromentin, Emilie, Shattock, Robin, Anton, Peter, Gorelick, Robert, Balzarini, Jan, McGuigan, Christopher, Derudas, Marco, Götte, Matthias, Schinazi, Raymond F and Margolis, Leonid (2008) Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host and Microbe, 4 (3). pp. 260-270. ISSN 1931-3128

McGuigan, Christopher, Derudas, Marco, Bugert, Joachim J, Andrei, Graciela, Snoeck, Robert and Balzarini, Jan (2008) Successful kinase bypass with new acyclovir phosphoramidate prodrugs. Bioorganic and Medicinal Chemistry Letters, 18 (15). pp. 4364-4367. ISSN 0960-894X

Sechi, Mario, Bacchi, Alessia, Carcelli, Mauro, Compari, Carlotta, Duce, Elenia, Fisicaro, Emilia, Rogolino, Dominga, Gates, Paul, Derudas, Marco, Al-Mawsawi, Laith Q and Neamati, Nouri (2006) From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by β-diketo acid metal complexes. Journal of Medicinal Chemistry, 49 (14). pp. 4248-4260. ISSN 0022-2623

Book Section

Derudas, Marco and Meneghesso, Silvia (2015) The role of fluorine in antiviral drug discovery. In: Fluorinated Pharmaceuticals Advances in medicinal chemistry. Future Science Ltd, London. ISBN 9781909453968