Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

Shaw, K, Bell, L, Boyd, K, Grijseels, D M, Clarke, D, Bonnar, O, Crombag, H S and Hall, C N (2021) Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences. Nature Communications, 12. a3190 1-16. ISSN 2041-1723

[img] PDF - Accepted Version
Download (14MB)
[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB)

Abstract

The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer’s disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature may restrict oxygen availability and could explain its sensitivity to damage during neurological conditions, including Alzheimer’s disease, where the brain’s energy supply is decreased.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 29 Apr 2021 15:59
Last Modified: 01 Jun 2021 13:45
URI: http://sro.sussex.ac.uk/id/eprint/98733

View download statistics for this item

📧 Request an update