s41467-021-23508-y.pdf (3.98 MB)
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
Version 2 2023-06-12, 09:50
Version 1 2023-06-09, 23:44
journal contribution
posted on 2023-06-12, 09:50 authored by Kate ShawKate Shaw, L Bell, Katie Boyd, Dorieke Grijseels, D Clarke, Orla Bonnar, Hans CrombagHans Crombag, Catherine HallCatherine HallThe hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer’s disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature may restrict oxygen availability and could explain its sensitivity to damage during neurological conditions, including Alzheimer’s disease, where the brain’s energy supply is decreased.
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Publication status
- Published
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- Published version
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Nature CommunicationsISSN
2041-1723Publisher
Nature ResearchExternal DOI
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12Page range
1-16Article number
a3190Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-04-29First Open Access (FOA) Date
2021-06-01First Compliant Deposit (FCD) Date
2021-04-28Usage metrics
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