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FOWLER_Acta_Psychiatrica_Scandinavica_Apr_2021.pdf (233.73 kB)

The impact of manic symptoms in first-episode psychosis: findings from the UK National EDEN study

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posted on 2023-06-09, 23:37 authored by Steven Marwaha, Danielle Hett, Sonia Johnson, David FowlerDavid Fowler, Joanne Hodgekins, Nick Freemantle, Paul McCrone, Linda Everard, Peter Jones, Tim Amos, Swaran Singh, Vimal Sharma, Max Birchwood
Objective The extant literature is inconsistent over whether manic symptoms in first-episode psychosis (FEP) impact on its development and trajectory. This study addressed the following: (1) Does Duration of Untreated Illness (DUI) and Duration of Untreated Psychosis (DUP) differ between FEP patients with and without manic symptoms? (2) Do manic symptoms in FEP have an impact on time to remission over 1 year? Methods We used data from the National EDEN study, a longitudinal cohort of patients with FEP accessing early intervention services (EIS) in England, which measured manic, positive and negative psychotic symptoms, depression and functioning at service entry and 1 year. Data from 913 patients with FEP (639 without manic symptoms, 237 with manic symptoms) were analysed using both general linear modelling and survival analysis. Results Compared to FEP patients without manic symptoms, those with manic symptoms had a significantly longer DUI, though no difference in DUP. At baseline, people with manic symptoms had higher levels of positive and negative psychotic symptoms, depression and worse functioning. At 12 months, people with manic symptoms had significantly poorer functioning and more positive psychotic symptoms. The presence of manic symptoms delayed time to remission over 1 year. There was a 19% reduced rate of remission for people with manic symptoms compared to those without. Conclusions Manic symptoms in FEP are associated with delays to treatment. This poorer trajectory persists over 1 year. They appear to be a vulnerable and under-recognised group for poor outcome and need more focussed early intervention treatment.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Acta Psychiatrica Scandinavica

ISSN

0001-690X

Publisher

Wiley

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-04-15

First Open Access (FOA) Date

2022-04-17

First Compliant Deposit (FCD) Date

2021-04-15

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