Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation.pdf (1.67 MB)
Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
journal contribution
posted on 2023-06-09, 23:08 authored by Sergei Korneev, Jekaterina Garaliene, Gabriella TaylorGabriella Taylor, Ildiko KemenesIldiko Kemenes, George KemenesGeorge KemenesLong natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM.
Funding
Updating of memories during memory consolidation; G2208; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/P00766X/1
History
Publication status
- Published
File Version
- Published version
Journal
Scientific ReportsISSN
2045-2322Publisher
Nature ResearchExternal DOI
Volume
11Page range
1-9Article number
a3594Event location
EnglandDepartment affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-02-22First Open Access (FOA) Date
2021-02-22First Compliant Deposit (FCD) Date
2021-02-22Usage metrics
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