Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation

Korneev, Sergei, Garaliene, Jekaterina, Taylor, Gabriella, Kemenes, Ildikó and Kemenes, György (2021) Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation. Scientific Reports, 11. a3594 1-9. ISSN 2045-2322

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 22 Feb 2021 08:42
Last Modified: 22 Feb 2021 08:45
URI: http://sro.sussex.ac.uk/id/eprint/97305

View download statistics for this item

📧 Request an update