Journal of Gerontology Lymnaea review.pdf (799.11 kB)
The great pond snail (Lymnaea stagnalis) as a model of ageing and age-related memory impairment: an overview
journal contribution
posted on 2023-06-09, 22:59 authored by István Fodor, Réka Svigruha, George KemenesGeorge Kemenes, Ildiko KemenesIldiko Kemenes, Zsolt PirgerWith the increase of life span, normal ageing and age-related memory decline are affecting an increasing number of people; however, many aspects of these processes are still not fully understood. Although vertebrate models have provided considerable insights into the molecular and electrophysiological changes associated with brain ageing, invertebrates, including the widely recognised molluscan model organism, the great pond snail (Lymnaea stagnalis) have proven to be extremely useful for studying mechanisms of ageing at the level of identified individual neurons and well-defined circuits. It’s numerically simpler nervous system, well-characterized life cycle and relatively long lifespan make it an ideal organism to study age-related changes in the nervous system. Here, we provide an overview of age-related studies on L. stagnalis and showcase this species as a contemporary choice for modelling the molecular, cellular, circuit, and behavioural mechanisms of ageing and age-related memory impairment.
Funding
G2208; Updating of memories during memory consolidation; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/P00766X/1
History
Publication status
- Published
File Version
- Accepted version
Journal
Journals of Gerontology, Series AISSN
1079-5006Publisher
Oxford University PressExternal DOI
Issue
6Volume
76Page range
975-982Event location
United StatesDepartment affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-02-05First Open Access (FOA) Date
2022-01-17First Compliant Deposit (FCD) Date
2021-02-05Usage metrics
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