Therapeutic potential of active components of saffron in post-surgical adhesion band formation

Arjmand, Mohammad-Hassan, Hashemzehi, Milad, Soleimani, Atena, Asgharzadeh, Fereshteh, Avan, Amir, Mehraban, Saeedeh, Fakhraei, Maryam, Ferns, Gordon A, Ryzhikov, Mikhail, Gharib, Masoumeh, Salari, Roshanak, Hoseinian, Sayyed Hadi Sayyed, Parizadeh, Mohammad Reza, Khazaei, Majid and Hassanian, Seyed Mahdi (2021) Therapeutic potential of active components of saffron in post-surgical adhesion band formation. Journal of Traditional and Complementary Medicine. pp. 1-8. ISSN 2225-4110

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Abstract

Background
Abdominal adhesions are common and often develop after abdominal surgery. There are currently no useful targeted pharmacotherapies for adhesive disease. Saffron and its active constituents, Crocin and Crocetin, are wildly used in traditional medicine for alleviating the severity of inflammatory or malignant disease.

Purpose
The aim of this study was to investigate the therapeutic potential of the pharmacological active component of saffron in attenuating the formation of post-operative adhesion bands using different administration methods in a murine model.

Material method
saffron extract (100 mg/kg), Crocin (100 mg/kg), and Crocetin (100 mg/kg) were administered intraperitoneally and by gavage in various groups of male Wistar rat post-surgery. Also three groups were first treated intra-peritoneally by saffron extract, Crocin, and Crocetin (100 mg/kg) for 10 days and then had surgery. At the end of the experiments, animals sacrificed for biological assessment.

Result
A hydro-alcoholic extract of saffron and crocin but not crocetin potently reduced the adhesion band frequency in treatment and pre-treatment groups in the mice given intra-peritoneal (i.p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups.

Conclusion
These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials.

Taxonomy
Abdominal surgeries/post-surgical adhesions.

Item Type: Article
Keywords: Saffron, Crocin, Crocetin, Post-surgical adhesion band formation, Fibrosis, Inflammation
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 Jan 2021 08:19
Last Modified: 26 Jan 2021 08:30
URI: http://sro.sussex.ac.uk/id/eprint/96738

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