First, tau causes NO problem

Bonnar, Orla and Hall, Catherine N (2020) First, tau causes NO problem. Nature Neuroscience, 23 (9). pp. 1035-1036. ISSN 1097-6256

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Abstract

Pathological tau disrupts the association between nitric oxide (NO) synthase and PSD95, impairing NO signaling and neurovascular coupling before causing neurodegeneration. Stopping production of pathological tau rescues NO signaling, neurovascular coupling and neuronal function, but doesn’t remove tangles, suggesting that (like amyloid-β) soluble tau is an important driver of early neurovascular dysfunction and subsequent neuronal damage.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 28 Sep 2020 06:55
Last Modified: 11 Feb 2021 02:00
URI: http://sro.sussex.ac.uk/id/eprint/93971

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