Imaging pericytes and the regulation of cerebral blood flow

Boyd, Katie, Hammond-Haley, Matthew, Vroman, Rozan and Hall, Catherine N (2021) Imaging pericytes and the regulation of cerebral blood flow. In: Peault, Bruno M (ed.) Pericytes: methods and protocols. Methods in Molecular Biology . Springer Nature, pp. 89-117. ISBN 9781071610558

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Abstract

The brain’s high energy requirements drive the need for close coupling of local neuronal activity to blood supply. Capillaries have been shown to dilate before arterioles in response to sensory stimulation, pointing to a key role for microvascular pericytes in mediating cerebrovascular dynamics. However, many aspects of these cells’ function remain unknown and even controversial, from their identification, to the mechanism and regulation of their contractility in physiology and disease. Investigating how pericytes regulate vascular diameter is therefore likely to be the subject of many future experiments. Here we provide protocols for three different techniques (ex vivo slice imaging, in vivo imaging, and immunohistochemistry) that are highly valuable for performing such experiments.

Item Type: Book Section
Schools and Departments: School of Psychology > Psychology
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 11 Sep 2020 08:30
Last Modified: 22 Apr 2021 13:34
URI: http://sro.sussex.ac.uk/id/eprint/93704

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