Neuronal network topology indicates distinct recovery processes after stroke

Latifi, Shahrzad, Mitchell, Simon, Habibey, Rouhollah, Hosseini, Fouzhan, Donzis, Elissa, Estrada-Sánchez, Ana María, Nejad, H Rezaei, Levine, Michael, Golshani, Peyman and Carmichael, S Thomas (2020) Neuronal network topology indicates distinct recovery processes after stroke. Cerebral Cortex. ISSN 1047-3211

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Abstract

Despite substantial recent progress in network neuroscience, the impact of stroke on the distinct features of reorganizing neuronal networks during recovery has not been defined. Using a functional connections-based approach through 2-photon in vivo calcium imaging at the level of single neurons, we demonstrate for the first time the functional connectivity maps during motion and nonmotion states, connection length distribution in functional connectome maps and a pattern of high clustering in motor and premotor cortical networks that is disturbed in stroke and reconstitutes partially in recovery. Stroke disrupts the network topology of connected inhibitory and excitatory neurons with distinct patterns in these 2 cell types and in different cortical areas. These data indicate that premotor cortex displays a distinguished neuron-specific recovery profile after stroke.

Item Type: Article
Keywords: calcium imaging, stroke recovery, functional connectivity, network topology, two-photon microscopy
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Aug 2020 06:43
Last Modified: 05 Aug 2020 09:30
URI: http://sro.sussex.ac.uk/id/eprint/92913

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