Multi-omics technologies applied to tuberculosis drug discovery

Goff, Aaron, Cantillon, Dairre, Murano Wildner, Leticia and Waddell, Simon J (2020) Multi-omics technologies applied to tuberculosis drug discovery. Applied Sciences, 10 (13). a4629 1-20. ISSN 2076-3417

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Abstract

Multi-omics strategies are indispensable tools in the search for new anti-tuberculosis drugs. Omics methodologies, where the ensemble of a class of biological molecules are measured and evaluated together, enable drug discovery programs to answer two fundamental questions. Firstly, in a discovery biology approach, to find new targets in druggable pathways for target-based investigation, advancing from target to lead compound. Secondly, in a discovery chemistry approach, to identify the mode of action of lead compounds derived from high-throughput screens, progressing from compound to target. The advantage of multi-omics methodologies in both of these settings is that omics approaches are unsupervised and unbiased to a priori hypotheses, making omics useful tools to confirm drug action, reveal new insights into compound activity, and discover new avenues for inquiry. This review summarizes the application of Mycobacterium tuberculosis omics technologies to the early stages of tuberculosis antimicrobial drug discovery.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 22 Jul 2020 06:48
Last Modified: 22 Jul 2020 15:52
URI: http://sro.sussex.ac.uk/id/eprint/92681

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