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Multi-omics technologies applied to tuberculosis drug discovery

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posted on 2023-06-07, 07:35 authored by Aaron Goff, Daire Cantillon, Leticia Murano Wildner, Simon WaddellSimon Waddell
Multi-omics strategies are indispensable tools in the search for new anti-tuberculosis drugs. Omics methodologies, where the ensemble of a class of biological molecules are measured and evaluated together, enable drug discovery programs to answer two fundamental questions. Firstly, in a discovery biology approach, to find new targets in druggable pathways for target-based investigation, advancing from target to lead compound. Secondly, in a discovery chemistry approach, to identify the mode of action of lead compounds derived from high-throughput screens, progressing from compound to target. The advantage of multi-omics methodologies in both of these settings is that omics approaches are unsupervised and unbiased to a priori hypotheses, making omics useful tools to confirm drug action, reveal new insights into compound activity, and discover new avenues for inquiry. This review summarizes the application of Mycobacterium tuberculosis omics technologies to the early stages of tuberculosis antimicrobial drug discovery.

History

Publication status

  • Published

File Version

  • Published version

Journal

Applied Sciences

ISSN

2076-3417

Publisher

MDPI

Issue

13

Volume

10

Page range

1-20

Article number

a4629

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-07-22

First Open Access (FOA) Date

2020-07-22

First Compliant Deposit (FCD) Date

2020-07-22

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