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Quantifying the role of stochasticity in the development of autoimmune disease
journal contribution
posted on 2023-06-07, 07:05 authored by Lindsay B Nicholson, Konstantin BlyussKonstantin Blyuss, Farzad FatehiIn this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics. Stability analysis yields parameter regions associated with normal cell homeostasis, or sustained periodic oscillations. Variance of these oscillations and the effects of stochastic amplification are also explored. Theoretical results are complemented by experiments, in which experimental autoimmune uveoretinitis (EAU) was induced in B10.RIII and C57BL/6 mice. For both cases, we discuss peculiarities of disease development, the levels of variation in T cell populations in a population of genetically identical organisms, as well as a comparison with model outputs.
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- Published
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- Published version
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CellsISSN
2073-4409Publisher
MDPIExternal DOI
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9Page range
1-23Article number
a860Department affiliated with
- Mathematics Publications
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- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-05-26First Open Access (FOA) Date
2020-05-26First Compliant Deposit (FCD) Date
2020-05-24Usage metrics
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