Investigation of water vapour sorption mechanism of starch-based pharmaceutical excipients

Rajabnezhad, Saeid, Ghafourian, Taravat, Rajabi-Siahboomi, Ali, Missaghi, Shahrzad, Naderi, Majid, Salvage, Jonathan P and Nokhodchi, Ali (2020) Investigation of water vapour sorption mechanism of starch-based pharmaceutical excipients. Carbohydrate Polymers, 238. a116208. ISSN 0144-8617

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Abstract

Starch-based excipients are commonly used in oral solid dosage forms. The effect of particle size and pregelatinisation level of starch-based excipients on their water absorption behaviour have been evaluated. The results showed that starch-based excipients have type ii isotherms, indicating that the principal mechanism of sorption is the formation of monolayer coverage and multilayer water molecules (10–80 RH %). It was found that the particle size of starch-based excipients did not have any influence on the rate of water sorption, whereas the level of pregelatinisation changed the kinetics of water sorption-desorption. Results showed that the higher the degree of pregelatinisation, the higher the rate of water absorption, which is irrespective of particle size. SEM images showed that a partially gelatinised starch had a firm granular structure with small pores and channels on the surface while a fully gelatinised starch had more irregular and spongy like surface with a degree of fractured particles.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0071 Analytical chemistry
R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0189 Assay methods. Standardization. Analysis
Depositing User: Ali Nokhodchi
Date Deposited: 04 May 2020 06:54
Last Modified: 24 Mar 2021 02:00
URI: http://sro.sussex.ac.uk/id/eprint/91142

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