Loss of functional pRB is not a ubiquitous feature of B-cell malignancies.pdf (146.78 kB)
Loss of functional pRB is not a ubiquitous feature of B-cell malignancies
journal contribution
posted on 2023-06-07, 06:55 authored by Alison Sinclair, V FrostHuman cancers frequently sustain genetic mutations that alter the function of their G1 cell cycle control check point. These include changes to the retinoblastoma gene and to the genes that regulate its phosphorylation, such as the cyclin-dependent kinase inhibitor p16(INK4a). Altered expression of retinoblastoma protein (pRb) is associated with non-Hodgkin's lymphoma, particularly centroblastic and Burkitt's lymphomas. pRb is expressed in normal B-cells and its regulatory phosphorylation pathway is activated in response to a variety of stimuli. Since human B-lymphoma-derived cell lines are often used as in vitro model systems to analyse the downstream effects of signal transduction, we examined the functional status of pRb in a panel of human B-cell lines. We identified eleven cell lines which express the hyperphosphorylated forms of pRb. Furthermore, we suggest that the pRb protein appears to be functional in these cell lines.
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Publication status
- Published
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- Published version
Journal
British Journal of CancerISSN
0007-0920Publisher
Springer NatureExternal DOI
Volume
80Page range
670-675Event location
EnglandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-05-01First Open Access (FOA) Date
2020-05-01First Compliant Deposit (FCD) Date
2020-05-01Usage metrics
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