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Loss of functional pRB is not a ubiquitous feature of B-cell malignancies.pdf (146.78 kB)

Loss of functional pRB is not a ubiquitous feature of B-cell malignancies

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journal contribution
posted on 2023-06-07, 06:55 authored by Alison Sinclair, V Frost
Human cancers frequently sustain genetic mutations that alter the function of their G1 cell cycle control check point. These include changes to the retinoblastoma gene and to the genes that regulate its phosphorylation, such as the cyclin-dependent kinase inhibitor p16(INK4a). Altered expression of retinoblastoma protein (pRb) is associated with non-Hodgkin's lymphoma, particularly centroblastic and Burkitt's lymphomas. pRb is expressed in normal B-cells and its regulatory phosphorylation pathway is activated in response to a variety of stimuli. Since human B-lymphoma-derived cell lines are often used as in vitro model systems to analyse the downstream effects of signal transduction, we examined the functional status of pRb in a panel of human B-cell lines. We identified eleven cell lines which express the hyperphosphorylated forms of pRb. Furthermore, we suggest that the pRb protein appears to be functional in these cell lines.

History

Publication status

  • Published

File Version

  • Published version

Journal

British Journal of Cancer

ISSN

0007-0920

Publisher

Springer Nature

Volume

80

Page range

670-675

Event location

England

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-05-01

First Open Access (FOA) Date

2020-05-01

First Compliant Deposit (FCD) Date

2020-05-01