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The prognostic value of cyclin D1 expression in the survival of cancer patients: a meta-analysis

journal contribution
posted on 2023-06-09, 20:06 authored by Maryam Moradi Binabaj, Afsane Bahram, Majid Khazaei, Mikhail Ryzhikov, Gordon FernsGordon Ferns, Seyed Mahdi Hassanian
Background The relationship between the expression of cyclin D1 and cancer prognosis and outcomes in different malignancies has not been fully elucidated. Aims In the presented meta-analysis, we assessed the association between the expression level of cyclin D1 with overall survival (OS) in several cancers. Methods Eligible studies were identified using PubMed, EMBase, Scopus, Web of Sciences and Cochrane Library databases. For the prognostic meta-analysis, study-specific hazard ratios (HRs) of tissue cyclin D1 for survival were obtained. Finally we pooled data derived from one hundred and eight studies comprising 19,224 patients with 10 different cancer types. Results In the pooled analysis, high expression of cyclin D1 was significantly related to a poor OS with a pooled HR of 1.11 (95% CI: 1.02–1.20, P = 0.015; random-effects). Sub-group analysis revealed that high expression of cyclin D1 was related to worse OS of head and neck cancers (HR = 2.08, 95% CI: 1.75–2.47; P < 0.001), but not in breast (HR = 1.033, 95% CI: 0.873–1.223, P = 0.702), gastrointestinal (HR = 1.025, 95% CI:0.824–1.275; P = 0.825), bladder (HR = 0.937, CI: 0.844–1.041; P = 0.225) and in lung cancer patients (HR = 1.092, CI: 0.819–1.455; P = 0.549). Conclusion Further large, prospective, and well-designed trials are warranted to elucidate the precise clinical importance of cyclin D1 overexpression in the prognosis of cancer patients receiving different treatment regimens.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Gene

ISSN

0378-1119

Publisher

Elsevier

Volume

728

Article number

a144283

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-01-06

First Open Access (FOA) Date

2020-12-13

First Compliant Deposit (FCD) Date

2020-01-03

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