__smbhome.uscs.susx.ac.uk_tjk30_Documents_untitled.pdf (655 kB)
HEART UK Consensus Statement on Lipoprotein(a) - a call to action
journal contribution
posted on 2023-06-09, 19:53 authored by Jaimini Cegla, R Dermot G Neely, Michael France, Gordon FernsGordon Ferns, Chris D Byrne, Julian Halcox, Dev Datta, Nigel Capps, Carol Shoulders, Nadeem Qureshi, Alan Rees, Linda Main, Robert Cramb, Adie Viljoen, Jules Payne, Handrean SoranLipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a). HEART UK recommends that Lp(a) is measured in adults as follows: 1)those with a personal or family history of premature atherosclerotic CVD; 2)those with first-degree relatives who have Lp(a)levels > 200nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but<15%) 10 year risk of a cardiovascular event. The management of patients with raised Lp(a) levels should include: 1) reducing overall atherosclerotic risk; 2)controlling dyslipidemia with a desirable nonHDL-cholesterol level of <100mg/d (2.5mmol/l) and 3) consideration of lipoprotein apheresis.
History
Publication status
- Published
File Version
- Published version
Journal
AtherosclerosisISSN
0021-9150Publisher
ElsevierVolume
291Page range
62-70Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-12-09First Open Access (FOA) Date
2019-12-09First Compliant Deposit (FCD) Date
2019-12-09Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC