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Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine
journal contribution
posted on 2023-06-09, 18:12 authored by Bryan SingerBryan Singer, Myranda A Bryan, Pavlo Popov, Terry E Robinson, Brandon J AragonaRepeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-hours later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.
History
Publication status
- Published
File Version
- Accepted version
Journal
Behavioural Brain ResearchISSN
01664328Publisher
ElsevierExternal DOI
Volume
324Page range
66-70Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-06-24First Open Access (FOA) Date
2019-06-24First Compliant Deposit (FCD) Date
2019-06-24Usage metrics
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