Synaptic convergence patterns onto retinal ganglion cells are preserved despite topographic variation in pre- and postsynaptic territories

Yu, Wan-Qing, El-Danaf, Rana N, Okawa, Haruhisa, Pacholec, Justin M, Matti, Ulf, Schwarz, Karin, Odermatt, Benjamin, Dunn, Felice A, Lagnado, Leon, Schmitz, Frank, Huberman, Andrew D and Wong, Rachel O L (2018) Synaptic convergence patterns onto retinal ganglion cells are preserved despite topographic variation in pre- and postsynaptic territories. Cell Reports, 25 (8). 2017-2026.e3. ISSN 2211-1247

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Abstract

Sensory processing can be tuned by a neuron’s integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the postsynaptic retinal ganglion cell (RGC) dendritic territories and their presynaptic bipolar cell (BC) axonal territories are either matched or unmatched. Despite this difference, in both circuits, the proportion of inputs from each BC type, i.e., synaptic convergence between specific BCs and RGCs, remained constant across varying dendritic territory sizes. Furthermore, synapse density between BCs and RGCs was invariant across topography. Our results demonstrate a wiring design, likely engaging homotypic axonal tiling of BCs, that ensures consistency in synaptic convergence between specific BC types onto their target RGCs while enabling independent regulation of pre- and postsynaptic territory sizes and synapse number between cell pairs.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Depositing User: Leon Lagnado
Date Deposited: 03 Apr 2019 12:24
Last Modified: 25 May 2021 07:45
URI: http://sro.sussex.ac.uk/id/eprint/82967

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Project NameSussex Project NumberFunderFunder Ref
Synaptic computation in the visual systemG1321WELLCOME TRUST102905/Z/13/Z