Wong_2018.pdf (4.48 MB)
Synaptic convergence patterns onto retinal ganglion cells are preserved despite topographic variation in pre- and postsynaptic territories
journal contribution
posted on 2023-06-09, 17:28 authored by Wan-Qing Yu, Rana N El-Danaf, Haruhisa Okawa, Justin M Pacholec, Ulf Matti, Karin Schwarz, Benjamin Odermatt, Felice A Dunn, Leon LagnadoLeon Lagnado, Frank Schmitz, Andrew D Huberman, Rachel O L WongSensory processing can be tuned by a neuron’s integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the postsynaptic retinal ganglion cell (RGC) dendritic territories and their presynaptic bipolar cell (BC) axonal territories are either matched or unmatched. Despite this difference, in both circuits, the proportion of inputs from each BC type, i.e., synaptic convergence between specific BCs and RGCs, remained constant across varying dendritic territory sizes. Furthermore, synapse density between BCs and RGCs was invariant across topography. Our results demonstrate a wiring design, likely engaging homotypic axonal tiling of BCs, that ensures consistency in synaptic convergence between specific BC types onto their target RGCs while enabling independent regulation of pre- and postsynaptic territory sizes and synapse number between cell pairs.
Funding
Synaptic computation in the visual system; G1321; WELLCOME TRUST; 102905/Z/13/Z
History
Publication status
- Published
File Version
- Published version
Journal
Cell ReportsISSN
2211-1247Publisher
ElsevierExternal DOI
Issue
8Volume
25Page range
2017-2026.e3Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-04-03First Open Access (FOA) Date
2019-04-03First Compliant Deposit (FCD) Date
2019-04-03Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC