Ribbon synapses and visual processing in the retina

Lagnado, Leon and Schmitz, Frank (2015) Ribbon synapses and visual processing in the retina. Annual Review of Vision Science, 1. pp. 235-262. ISSN 2374-4650

[img] PDF - Published Version
Restricted to SRO admin only

Download (2MB)

Abstract

The first synapses transmitting visual information contain an unusual organelle, the ribbon, which is involved in the transport and priming of vesicles to be released at the active zone. The ribbon is one of many design features that allow efficient refilling of the active zone, which in turn enables graded changes in membrane potential to be transmitted using a continuous mode of neurotransmitter release. The ribbon also plays a key role in supplying vesicles for rapid and transient bursts of release that signal fast changes, such as the onset of light. We increasingly understand how the physiological properties of ribbon synapses determine basic transformations of the visual signal and, in particular, how the process of refilling the active zone regulates the gain and adaptive properties of the retinal circuit. The molecular basis of ribbon function is, however, far from clear.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Depositing User: Leon Lagnado
Date Deposited: 03 Apr 2019 11:27
Last Modified: 26 Apr 2021 14:30
URI: http://sro.sussex.ac.uk/id/eprint/82964

View download statistics for this item

📧 Request an update