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Mathematical and computational models of the retina in health, development and disease
journal contribution
posted on 2023-06-09, 17:14 authored by Paul Roberts, Eamonn A Gaffney, Philip J Luthert, Alexander J E Foss, Helen M ByrneThe retina confers upon us the gift of vision, enabling us to perceive the world in a manner unparalleled by any other tissue. Experimental and clinical studies have provided great insight into the physiology and biochemistry of the retina; however, there are questions which cannot be answered using these methods alone. Mathematical and computational techniques can provide complementary insight into this inherently complex and nonlinear system. They allow us to characterise and predict the behaviour of the retina, as well as to test hypotheses which are experimentally intractable. In this review, we survey some of the key theoretical models of the retina in the healthy, developmental and diseased states. The main insights derived from each of these modelling studies are highlighted, as are model predictions which have yet to be tested, and data which need to be gathered to inform future modelling work. Possible directions for future research are also discussed. Whilst the present modelling studies have achieved great success in unravelling the workings of the retina, they have yet to achieve their full potential. For this to happen, greater involvement with the modelling community is required, and stronger collaborations forged between experimentalists, clinicians and theoreticians. It is hoped that, in addition to bringing the fruits of current modelling studies to the attention of the ophthalmological community, this review will encourage many such future collaborations.
History
Publication status
- Published
File Version
- Accepted version
Journal
Progress in Retinal and Eye ResearchISSN
1350-9462Publisher
ElsevierExternal DOI
Volume
53Page range
48-69Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2019-03-12First Compliant Deposit (FCD) Date
2019-03-11Usage metrics
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