Herman2019_Article_TheImpactOfYohimbine-inducedAr.pdf (797.04 kB)
The impact of yohimbine-induced arousal on facets of behavioural impulsivity
Version 2 2023-06-12, 08:58
Version 1 2023-06-09, 16:32
journal contribution
posted on 2023-06-12, 08:58 authored by Aleksandra Herman, Hugo CritchleyHugo Critchley, Dora DukaRationale State-dependent changes in physiological arousal may influence impulsive behaviours. Objectives To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an a2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performance on established laboratory-based impulsivity measures in healthy volunteers. Methods Forty-three participants received a single dose of either yohimbine hydrochloride or placebo before completing a battery of impulsivity measures. Blood pressure and heart rate were monitored throughout the study. Results Participants in the yohimbine group showed higher blood pressure and better response inhibition in the Stop Signal Task, relative to the placebo group. Additionally, individual changes in blood pressure were associated with performance on Delay Discounting and Information Sampling tasks: raised blood pressure following drug ingestion was associated with more far-sighted decisions in the Delay Discounting Task (lower temporal impulsivity) yet reduced information gathering in the Information Sampling Task (increased reflection impulsivity). Conclusions These results support the notion that impulsive behaviour is dependent upon state physiological arousal; however, distinct facets of impulsivity are differentially affected by physiological changes.
History
Publication status
- Published
File Version
- Published version
Journal
PsychopharmacologyISSN
0033-3158Publisher
Springer VerlagExternal DOI
Department affiliated with
- BSMS Publications
Research groups affiliated with
- Sackler Centre for Consciousness Science Publications
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-01-16First Open Access (FOA) Date
2019-01-16First Compliant Deposit (FCD) Date
2019-01-15Usage metrics
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