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Variation at the TRIM11 locus modifies Progressive Supranuclear Palsy phenotype

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journal contribution
posted on 2023-06-12, 11:23 authored by Edwin Jabbari, John Woodside, Manueal M X Tan, Maryam Shoai, Alan Pittman, Raffaele Ferrari, Kin Y Mok, David Zhang, Regina H Reynolds, Rohan de Silva, Max-Joseph Grimm, Gesine Respondek, Ulrich Müller, Safa Al-Sarraj, Stephen M Gentleman, Andrew J Lees, Thomas T Warner, John Hardy, Tamas Revesz, Günter U Höglinger, Janice L Holton, Mina Ryten, Huw R Morris, Nigel LeighNigel Leigh, PROSPECT-UK consortium
OBJECTIVE The basis for clinical variation related to underlying Progressive Supranuclear Palsy (PSP) pathology is unknown. We performed a genome wide association study (GWAS) to identify genetic determinants of PSP phenotype. METHODS Two independent pathological and clinically diagnosed PSP cohorts were genotyped and phenotyped to create Richardson's syndrome (RS) and non-RS groups. We carried out separate logistic regression GWAS to compare RS and non-RS groups and then combined datasets to carry out a whole cohort analysis (RS=367, non-RS=130). We validated our findings in a third cohort by referring to data from 100 deeply phenotyped cases from a recent GWAS. We assessed the expression/co-expression patterns of our identified genes and used our data to carry out gene-based association testing. RESULTS Our lead single nucleotide polymorphism (SNP), rs564309, showed an association signal in both cohorts, reaching genome wide significance in our whole cohort analysis - OR 5.5 (3.2-10.0), p-value 1.7x10 . rs564309 is an intronic variant of the tripartite motif-containing protein 11 (TRIM11) gene, a component of the ubiquitin proteasome system (UPS). In our third cohort, minor allele frequencies of surrogate SNPs in high linkage disequilibrium with rs564309 replicated our findings. Gene based association testing confirmed an association signal at TRIM11. We found that TRIM11 is predominantly expressed neuronally, in the cerebellum and basal ganglia. INTERPRETATION Our study suggests that the TRIM11 locus is a genetic modifier of PSP phenotype and potentially adds further evidence for the UPS having a key role in tau pathology, therefore representing a target for disease modifying therapies. This article is protected by copyright. All rights reserved.

History

Publication status

  • Published

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  • Published version

Journal

Annals of Neurology

ISSN

0364-5134

Publisher

John Wiley & Sons

Issue

4

Volume

84

Page range

485-496

Department affiliated with

  • BSMS Neuroscience Publications

Notes

Prof Nigel Leigh contributed to this research output as part of the PROSPECT-UK consortium

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-08

First Open Access (FOA) Date

2019-07-16

First Compliant Deposit (FCD) Date

2018-08-08

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