accepted track change-miRNAsandCervicalcancerJCP.pdf (1.13 MB)
The potential prognostic and therapeutic application of tissue and circulating microRNAs in cervical cancer
journal contribution
posted on 2023-06-09, 14:13 authored by Malihe Hasanzadeh, Mehraneh Movahedi, Marzieh Rejali, Faezeh Maleki, Mehrdad Moetamani-Ahmadi, Sima Seifi, Zeinab Hosseini, Majid Khazaei, Forouzan Amerizadeh, Gordon FernsGordon Ferns, Majid Rezayi, Amir AvanCervical cancer (CC) is a common malignancy in women and a major cause of cancer- related mortality globally. Some novel biomarkers may enable the early diagnosis and monitoring of CC. MicroRNAs are small noncoding RNAs that control gene translation at a post transcriptional level. Hence the deregulation of these molecules can cause many diseases. There appears to be an association between aberrant miRNA expression and CC, but the molecular mechanisms involved in the development of CC remain unknown. The upregulation of some circulating miRNAs, e.g. miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue specific-miRNAs, e.g. miR-7, miR-10a, miR-17-5p, miR-135b, miR-149 and miR-203 has been found in patients with CC. There is also growing evidence for the importance of miRNAs in the development of drug-resistance. This review therefore highlights recently published preclinical and clinical investigation performed on tissue-specific and circulating miRNAs, as potential biomarkers for the detection of patients at early stages of CC, in the prediction of prognosis, and monitoring of their response to therapy. Key word: cervical cancer, CIN, MiRNA, circulating biomarker, tissue-specific biomarker, HPV
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular PhysiologyISSN
0021-9541Publisher
WileyExternal DOI
Issue
2Volume
234Page range
1289-1294Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-07-20First Open Access (FOA) Date
2019-09-07First Compliant Deposit (FCD) Date
2018-07-20Usage metrics
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