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Factors affecting the nuclear localization of ß-catenin in normal and malignant tissue

journal contribution
posted on 2023-06-09, 13:12 authored by Rhys MorganRhys Morgan, Jenna Ridsdale, Alex Tonks, Richard L Darley
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, ß-catenin. In particular, the nuclear localization of ß-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling ß-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of ß-catenin and how they are relevant to cancer.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Cellular Biochemistry

ISSN

0730-2312

Publisher

John Wiley & Sons

Issue

8

Volume

115

Page range

1351-1361

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2018-05-10

First Compliant Deposit (FCD) Date

2018-05-09

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