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Integrating DNA damage repair with the cell cycle
Abstract DNA is labile and constantly subject to damage. In addition to external mutagens, DNA is continuously damaged by the aqueous environment, cellular metabolites and is prone to strand breakage during replication. Cell duplication is orchestrated by the cell division cycle and specific DNA structures are processed differently depending on where in the cell cycle they are detected. This is often because a specific structure is physiological in one context, for example during DNA replication, while indicating a potentially pathological event in another, such as interphase or mitosis. Thus, contextualising the biochemical entity with respect to cell cycle progression provides information necessary to appropriately regulate DNA processing activities. We review the links between DNA repair and cell cycle context, drawing together recent advances.
Funding
Replication arrest, restart and genome instability; G1829; WELLCOME TRUST; 110047/Z/15/Z
How do Smc5/6 interactions with DNA coordinate replication and recombination?; G2119; MRC-MEDICAL RESEARCH COUNCIL; MR/P018955/1
History
Publication status
- Published
File Version
- Accepted version
Journal
Current Opinion in Cell BiologyISSN
0955-0674Publisher
ElsevierExternal DOI
Volume
52Page range
120-125Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Research groups affiliated with
- Genome Damage and Stability Centre Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-03-23First Open Access (FOA) Date
2019-03-26First Compliant Deposit (FCD) Date
2019-03-26Usage metrics
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