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Toll-like receptors: the key to the stable door?

journal contribution
posted on 2023-06-07, 16:05 authored by Philip Hopkins, Jonathan Cohen
Severe sepsis continues to lead to critical illness. Few therapeutic options exist other than antibiotic therapy and general supportive care. Large numbers of patients continue to die as a consequence of overactivation of the host inflammatory response and the resultant coagulopathy and disregulation of the normal controls of vasoactive tone. It is now known that a critical part of this host response occurs at the level of innate defence, without the need for antigen processing or the clonal expansion of cells targeted against the invading pathogen. This commentary will discuss the therapeutic targets revealed by our new understanding of the Toll-like receptor. The potential clinical difficulties that may result from intervention at this pattern-recognition receptor will also be explored.

History

Publication status

  • Published

Journal

Critical Care

ISSN

1364-8535

Publisher

BioMed Central

Issue

2

Volume

6

Page range

99-101

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2011-09-07

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