Kay_et_al-2018-Molecular_Neurobiology.pdf (1.34 MB)
Understanding miro GTPases: implications in the treatment of neurodegenerative disorders
journal contribution
posted on 2023-06-09, 11:56 authored by Laura Kay, Ilse Pienaar, Ruwini Cooray, Meera SoundararajanThe Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca2+-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegen- erative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.
History
Publication status
- Published
File Version
- Published version
Journal
Molecular NeurobiologyISSN
0893-7648Publisher
SpringerExternal DOI
Issue
9Volume
55Page range
7352-7365Department affiliated with
- Biology and Environmental Science Publications
Notes
Laura Kay and Ilse S. Pienaar contributed equally to this work (joint first-authors)Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-02-06First Open Access (FOA) Date
2018-02-06First Compliant Deposit (FCD) Date
2018-02-06Usage metrics
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