journal.pone.0001403.pdf (870.78 kB)
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
journal contribution
posted on 2023-06-07, 15:59 authored by Simon WaddellSimon Waddell, Ludovic Tailleux, Mattia Pelizzola, Alessandra Mortellaro, Michael Withers, Antoine Tanne, Paola Ricciardi Castagnoli, Brigitte Gicquel, Neil G Stoker, Philip D Butcher, Maria Foti, Olivier NeyrollesThis study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions. Our results also underline the extraordinary plasticity of host cell and pathogen responses to infection, and provide a solid framework to further understand the complex mechanisms involved in immunity to M. tuberculosis and in mycobacterial adaptation to different intracellular environments.
History
Publication status
- Published
File Version
- Published version
Journal
PLoS ONEISSN
1932-6203Publisher
Public Library of ScienceExternal DOI
Issue
1Volume
3Article number
e1403Department affiliated with
- Clinical and Experimental Medicine Publications
Notes
PubMed ID: 18167562Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2011-08-22First Open Access (FOA) Date
2016-03-22First Compliant Deposit (FCD) Date
2016-08-17Usage metrics
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