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Uncoupling of neurogenesis and differentiation during retinal development

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posted on 2023-06-09, 08:14 authored by Peter Engerer, Sachihiro Suzuki, Takeshi YoshimatsuTakeshi Yoshimatsu, Prisca Chapouton, Nancy Obeng, Benjamin Odermatt, Philip Williams, Thomas Misgeld, Leanne Godinho
Conventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and differentiation. We demonstrate that this notion is not a general principle of neuronal development by documenting the timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina using in vivo imaging. We found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages of neuronal differentiation. Remarkably, the differentiation state of individual BC progenitors at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surround. By experimentally shifting the relative timing of progenitor division and differentiation, we provide evidence that neurogenesis and differentiation can occur independently of each other. We propose that the uncoupling of neurogenesis and differentiation could provide neurogenic programs with flexibility, while allowing for synchronous neuronal development within a continuously expanding cell pool.

History

Publication status

  • Published

File Version

  • Published version

Journal

The EMBO Journal

ISSN

0261-4189

Publisher

Nature Publishing Group

Issue

9

Volume

36

Page range

1134-1146

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-10-11

First Open Access (FOA) Date

2017-10-11

First Compliant Deposit (FCD) Date

2017-10-11

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