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Uncoupling of neurogenesis and differentiation during retinal development
journal contribution
posted on 2023-06-09, 08:14 authored by Peter Engerer, Sachihiro Suzuki, Takeshi YoshimatsuTakeshi Yoshimatsu, Prisca Chapouton, Nancy Obeng, Benjamin Odermatt, Philip Williams, Thomas Misgeld, Leanne GodinhoConventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and differentiation. We demonstrate that this notion is not a general principle of neuronal development by documenting the timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina using in vivo imaging. We found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages of neuronal differentiation. Remarkably, the differentiation state of individual BC progenitors at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surround. By experimentally shifting the relative timing of progenitor division and differentiation, we provide evidence that neurogenesis and differentiation can occur independently of each other. We propose that the uncoupling of neurogenesis and differentiation could provide neurogenic programs with flexibility, while allowing for synchronous neuronal development within a continuously expanding cell pool.
History
Publication status
- Published
File Version
- Published version
Journal
The EMBO JournalISSN
0261-4189Publisher
Nature Publishing GroupExternal DOI
Issue
9Volume
36Page range
1134-1146Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-11First Open Access (FOA) Date
2017-10-11First Compliant Deposit (FCD) Date
2017-10-11Usage metrics
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