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Acoustic force measurements on polymer-coated microbubbles in a microfluidic device

journal contribution
posted on 2023-06-09, 06:20 authored by Gianluca MemoliGianluca Memoli, Christopher R Fury, Kate O Baxter, Pierre N Gélat, Philip H Jones
This work presents an acoustofluidic device for manipulating coated microbubbles, designed for the simultaneous use of optical and acoustical tweezers. A comprehensive characterization of the acoustic pressure in the device is presented, obtained by the synergic use of different techniques in the range of acoustic frequencies where visual observations showed aggregation of polymer-coated microbubbles. In absence of bubbles, the combined use of laser vibrometry and finite element modelling supported a non-invasive measurement of the acoustic pressure and an enhanced understanding of the system resonances. Calibrated holographic optical tweezers were used for direct measurements of the acoustic forces acting on an isolated microbubble, at low driving pressures, and to confirm the spatial distribution of the acoustic field. This allowed quantitative acoustic pressure measurements by particle tracking, using polystyrene beads, and an evaluation of the related uncertainties. This process facilitated the extension of tracking to microbubbles, which have a negative acoustophoretic contrast factor, allowing acoustic force measurements on bubbles at higher pressures than optical tweezers, highlighting four peaks in the acoustic response of the device. Results and methodologies are relevant to acoustofluidic applications requiring a precise characterization of the acoustic field and, in general, to biomedical applications with microbubbles or deformable particles.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of the Acoustical Society of America

ISSN

0001-4966

Publisher

Acoustical Society of America

Issue

5

Volume

141

Page range

3364-3378

Department affiliated with

  • Informatics Publications

Research groups affiliated with

  • Creative Technology Publications

Notes

work was funded by the National Physical Laboratory Strategic Research Fund

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-05-19

First Open Access (FOA) Date

2017-11-19

First Compliant Deposit (FCD) Date

2017-05-19

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