University of Sussex
Browse
bhx019-1.pdf (529.5 kB)

Interspersed distribution of selectivity to kinematic stimulus features in supragranular layers of mouse barrel cortex

Download (529.5 kB)
journal contribution
posted on 2023-06-09, 04:37 authored by Francisco J Martini, Manuel Molano-Mazón, Miguel Maravall RodriguezMiguel Maravall Rodriguez
Neurons in the primary sensory regions of neocortex have heterogeneous response properties. The spatial arrangement of neurons with particular response properties is a key aspect of population representations and can shed light on how local circuits are wired. Here we investigated how neurons with sensitivity to different kinematic features of whisker stimuli are distributed across local circuits in supragranular layers of the barrel cortex. Using two-photon calcium population imaging in anesthetized mice, we found that nearby neurons represent diverse kinematic features, providing a rich population representation at the local scale. Neurons interspersed in space therefore responded differently to a common stimulus kinematic feature. Conversely, neurons with similar feature selectivity were located no closer to each other than predicted by a random distribution null hypothesis. This finding relied on defining a null hypothesis that was specific for testing the spatial distribution of tuning across neurons. We also measured how neurons sensitive to specific features were distributed relative to barrel boundaries, and found no systematic organization. Our results are compatible with randomly distributed selectivity to kinematic features, with no systematic ordering superimposed upon the whisker map.

Funding

Valencia Regional Government; ACOMP2010/199

Spanish Ministry of Science and Innovation; BFU2011-23049

Sensory sequence representation and discrimination in cortical circuits; G1975; MRC-Medical Research Council; MR/P006639/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Cerebral Cortex

ISSN

1047-3211

Publisher

Oxford University Press

Issue

7

Volume

27

Page range

3782-2789

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-03-09

First Open Access (FOA) Date

2017-03-09

First Compliant Deposit (FCD) Date

2017-03-09

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC