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Interspersed distribution of selectivity to kinematic stimulus features in supragranular layers of mouse barrel cortex
journal contribution
posted on 2023-06-09, 04:37 authored by Francisco J Martini, Manuel Molano-Mazón, Miguel Maravall RodriguezMiguel Maravall RodriguezNeurons in the primary sensory regions of neocortex have heterogeneous response properties. The spatial arrangement of neurons with particular response properties is a key aspect of population representations and can shed light on how local circuits are wired. Here we investigated how neurons with sensitivity to different kinematic features of whisker stimuli are distributed across local circuits in supragranular layers of the barrel cortex. Using two-photon calcium population imaging in anesthetized mice, we found that nearby neurons represent diverse kinematic features, providing a rich population representation at the local scale. Neurons interspersed in space therefore responded differently to a common stimulus kinematic feature. Conversely, neurons with similar feature selectivity were located no closer to each other than predicted by a random distribution null hypothesis. This finding relied on defining a null hypothesis that was specific for testing the spatial distribution of tuning across neurons. We also measured how neurons sensitive to specific features were distributed relative to barrel boundaries, and found no systematic organization. Our results are compatible with randomly distributed selectivity to kinematic features, with no systematic ordering superimposed upon the whisker map.
Funding
Valencia Regional Government; ACOMP2010/199
Spanish Ministry of Science and Innovation; BFU2011-23049
Sensory sequence representation and discrimination in cortical circuits; G1975; MRC-Medical Research Council; MR/P006639/1
History
Publication status
- Published
File Version
- Published version
Journal
Cerebral CortexISSN
1047-3211Publisher
Oxford University PressExternal DOI
Issue
7Volume
27Page range
3782-2789Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-03-09First Open Access (FOA) Date
2017-03-09First Compliant Deposit (FCD) Date
2017-03-09Usage metrics
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