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Crossover inhibition generates sustained visual responses in the inner retina

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posted on 2023-06-09, 04:04 authored by Juliana M Rosa, Sabine Ruehle, Huayu Ding, Leon LagnadoLeon Lagnado
In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate these sustained channels within the inner retina of zebrafish. In OFF bipolar cells, sustained transmission was found to depend on crossover inhibition from the ON pathway through GABAergic amacrine cells. In ON bipolar cells, the amplitude of low-frequency signals was regulated by glycinergic amacrine cells, while GABAergic inhibition regulated the gain of band-pass signals. We also provide the first functional description of a subset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at frequencies above ~0.2 Hz. These results map out the basic circuitry by which the inner retina generates sustained visual signals and describes a new function of crossover inhibition.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neuron

ISSN

1097-4199

Publisher

Elsevier

Issue

2

Volume

90

Page range

308-19

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-11-21

First Open Access (FOA) Date

2017-11-21

First Compliant Deposit (FCD) Date

2017-11-21

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