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Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment

journal contribution
posted on 2023-06-09, 02:30 authored by Feng Bai, Zhijun Zhang, David R Watson, Hui Yu, Yongmei Shi, Yonggui Yuan, Yun Qian, Jianping Jia
The association fiber tracts integrity of the inter-hemispheric and within-hemispheric communication was poor understood in amnestic type mild cognitive impairment (aMCI) patients by diffusion tensor imaging (DTI). A region of interest-based DTI approach was applied to explore fiber tract differences between 22 aMCI patients and 22 well-matched normal aging. Correlations were also sought between fractional anisotropy (FA) values and the cognitive performance scores in the aMCI patients. Extensive impairment of association fiber tracts integrity was observed in aMCI patients, including bilateral inferior fronto-occipital fascicles, the genu of corpus callosum, bilateral cingulate bundles and bilateral superior longitudinal fascicles II (SLE II) subcomponent. In addition, the FA value of right SLE II was significantly negatively correlated to the performance of Trail Making Test A and B, whilst the values of right posterior cingulate bundle was significantly positive correlation with MMSE score. As aMCI is a putative prodromal syndrome to Alzheimer's disease (AD), this study suggested that investigation of association fiber tracts between remote cortexes may yield important new data to predict whether a patient will eventually develop AD.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of the Neurological Sciences

ISSN

0022-510X

Publisher

Elsevier

Issue

1-2

Volume

278

Page range

102-106

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-10

First Compliant Deposit (FCD) Date

2016-08-10

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