Bai et al. - 2011 - Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects a longitudinal resting--annotated.pdf (398.22 kB)
Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects: a longitudinal resting-state study
journal contribution
posted on 2023-06-09, 02:30 authored by Feng Bai, Chunming Xie, David R Watson, Yongmei Shi, Yonggui Yuan, Yi Wang, Chunxian Yue, Yuhuan Teng, Di Wu, Zhijun ZhangBackground: Altered hippocampal structure and function is a valuable indicator of possible conversion from amnestic type mild cognitive impairment (aMCI) to Alzheimer’s disease (AD). However, little is known about the disrupted functional connectivity of hippocampus subregional networks in aMCI subjects. Methodology/Principal Findings: aMCI group-1 (n = 26) and controls group-1 (n = 18) underwent baseline and after approximately 20 months follow up resting-state fMRI scans. Integrity of distributed functional connectivity networks incorporating six hippocampal subregions (i.e. cornu ammonis, dentate gyrus and subicular complex, bilaterally) was then explored over time and comparisons made between groups. The ability of these extent longitudinal changes to separate unrelated groups of 30 subjects (aMCI-converters, n = 6; aMCI group-2, n = 12; controls group-2, n = 12) were further assessed. Six longitudinal hippocampus subregional functional connectivity networks showed similar changes in aMCI subjects over time, which were mainly associated with medial frontal gyrus, lateral temporal cortex, insula, posterior cingulate cortex (PCC) and cerebellum. However, the disconnection of hippocampal subregions and PCC may be a key factor of impaired episodic memory in aMCI, and the functional index of these longitudinal changes allowed well classifying independent samples of aMCI converters from non-converters (sensitivity was 83.3%, specificity was 83.3%) and controls (sensitivity was 83.3%, specificity was 91.7%). Conclusions/Significance: It demonstrated that the functional changes in resting-state hippocampus subregional networks could be an important and early indicator for dysfunction that may be particularly relevant to early stage changes and progression of aMCI subjects.
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Publication status
- Published
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- Published version
Journal
PLoS BiologyISSN
1544-9173Publisher
Public Library of ScienceExternal DOI
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12Volume
6Article number
e29288-e29288Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-08-10First Open Access (FOA) Date
2016-08-10First Compliant Deposit (FCD) Date
2016-08-10Usage metrics
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