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Structural changes in the hippocampus and amygdala at first episode of psychosis

journal contribution
posted on 2023-06-09, 02:28 authored by David R Watson, Feng Bai, Suzanne L Barrett, Aidan Turkington, Teresa M Rushe, Ciaran C Mulholland, Stephen J Cooper
Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD). However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.

History

Publication status

  • Published

File Version

  • Published version

Journal

Brain Imaging and Behavior

ISSN

1931-7557

Publisher

Springer Verlag

Issue

1

Volume

6

Page range

49-60

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-09

First Compliant Deposit (FCD) Date

2016-08-09

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