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Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
journal contribution
posted on 2023-06-09, 01:17 authored by Nicos Angelopoulos, Justin Stebbing, Yichen Xu, Georgios GiamasGeorgios Giamas, Hua ZhangTyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier PXD002065.
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- Published
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- Published version
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Data in BriefISSN
2352-3409Publisher
ElsevierExternal DOI
Volume
7Page range
740-746Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-05-18First Open Access (FOA) Date
2016-05-18First Compliant Deposit (FCD) Date
2016-05-18Usage metrics
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