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Structural neural networks subserving oculomotor function in first-episode schizophrenia

journal contribution
posted on 2023-06-07, 13:37 authored by M S Bagary, S B Hutton, M R Symms, G J Barker, S H Mutsatsa, T R Barnes, E M Joyce, M A Ron
BACKGROUND: Smooth pursuit and antisaccade abnormalities are well documented in schizophrenia, but their neuropathological correlates remain unclear. METHODS: In this study, we used statistical parametric mapping to investigate the relationship between oculomotor abnormalities and brain structure in a sample of first-episode schizophrenia patients (n = 27). In addition to conventional volumetric magnetic resonance imaging, we also used magnetization transfer ratio, a technique that allows more precise tissue characterization. RESULTS: We found that smooth pursuit abnormalities were associated with reduced magnetization transfer ratio in several regions, predominantly in the right prefrontal cortex. Antisaccade errors correlated with gray matter volume in the right medial superior frontal cortex as measured by conventional magnetic resonance imaging but not with magnetization transfer ratio. CONCLUSIONS: These preliminary results demonstrate that specific structural abnormalities are associated with abnormal eye movements in schizophrenia.

History

Publication status

  • Published

Journal

Biological Psychiatry

ISSN

0006-3223

Publisher

Elsevier

Issue

9

Volume

56

Page range

620-627

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2006-12-07

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