PM_Harrison_Krishnadas_Commentary_PsychosomaticMed_PostReview.pdf (417.14 kB)
Depression phenotype, inflammation and the brain: implications for future research
journal contribution
posted on 2023-06-09, 00:45 authored by Rajeev Krishnadas, Neil HarrisonInflammation is implicated in the etiology of Major Depressive Disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation and cognition and its relationship to MDD. In this issue, Byrne and colleagues report the first systematic review of these studies. The systematic review provides a much-needed synthesis of current research findings and highlights the role of cortical and subcortical brain structure and function. In this accompanying commentary, we highlight further points of particular relevance to future studies, including the potential advantages of functional phenotype models rather than the emphasis on mutually exclusive diagnostic categories in describing MDD and other psychiatric disorders. Novel imaging techniques will further enhance possibilities to clarify the link between inflammation and depression. New research challenges are described regarding the relationships between behavioural phenotype, brain structure and function, and peripheral inflammation.
History
Publication status
- Published
File Version
- Accepted version
Journal
Psychosomatic MedicineISSN
0033-3174Publisher
Lippincott, Williams & WilkinsExternal DOI
Issue
4Volume
78Page range
384-388Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-04-04First Open Access (FOA) Date
2017-05-01First Compliant Deposit (FCD) Date
2016-04-04Usage metrics
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