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Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds
journal contribution
posted on 2023-06-08, 23:08 authored by Paolo Indiveri, Diana Alvarez-Muñoz, Pawel Rostkowski, Julia Horwood, Emily Greer, Christophe Minier, Nick Pope, William J Langston, Elizabeth M HillThis study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3 +/- 38.4 mu g flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms
History
Publication status
- Published
Journal
Marine Pollution BulletinISSN
0025-326XPublisher
ElsevierExternal DOI
Issue
2Volume
95Page range
590-597Department affiliated with
- Evolution, Behaviour and Environment Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-11-11Usage metrics
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