miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Letellier, Mathieu, Elramah, Sara, Mondin, Magali, Soula, Anaïs, Penn, Andrew, Choquet, Daniel, Landry, Marc, Thoumine, Olivier and Favereaux, Alexandre (2014) miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling. Nature Neuroscience, 17 (8). pp. 1040-1042. ISSN 1097-6256

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Abstract

We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3' untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Subjects: Q Science
Q Science > QH Natural history > QH0301 Biology
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Andrew Penn
Date Deposited: 07 Oct 2015 09:45
Last Modified: 09 Mar 2021 14:30
URI: http://sro.sussex.ac.uk/id/eprint/57011

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