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Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats
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posted on 2023-06-08, 22:18 authored by D A Booth, C W T Pilcher, G D D'Mello, I P Stolerman1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion). 2 There was very little difference between the potencies of (+)- and (-)-amphetamine. 3 p-Chloromethamphetamine was a more potent aversive agent than methamphetamine. 4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine. 5 Cocaine induced only moderate taste aversions, even at high doses. 6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.
History
Publication status
- Published
Journal
British Journal of PharmacologyISSN
0007-1188Publisher
Nature Publishing GroupIssue
4Volume
61Page range
669-677Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-01Usage metrics
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