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Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats

journal contribution
posted on 2023-06-08, 22:18 authored by D A Booth, C W T Pilcher, G D D'Mello, I P Stolerman
1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion). 2 There was very little difference between the potencies of (+)- and (-)-amphetamine. 3 p-Chloromethamphetamine was a more potent aversive agent than methamphetamine. 4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine. 5 Cocaine induced only moderate taste aversions, even at high doses. 6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.

History

Publication status

  • Published

Journal

British Journal of Pharmacology

ISSN

0007-1188

Publisher

Nature Publishing Group

Issue

4

Volume

61

Page range

669-677

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-09-01

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    University of Sussex (Publications)

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