Subcutaneous dialysis in the study of the effects of nutrients on feeding

A cellophane dialysis bag containing small molecular weight solids is implanted under the skin of the rat. Sodium chloride, glucose and hydrolyzed casein give differential effects on food and water intakes over the day following implantation. An uncompensated decrease in food intake is seen after administering glucose by this technique, as after rapid intraperitoneal or subcutaneous injection and unlike after either continuous intravenous infusion or rapid gastric intubation.