investigation-of-furo23-h-and-pyridazino34-fcinnolin-3-ol.pdf (410.4 kB)
Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors
journal contribution
posted on 2023-06-08, 21:49 authored by Mohamed F Y Gomaa, Nicolino Pala, Marco Derudas, Jehan Abd-Elrazik Hasanen, El-Sayed H El-Tamany, Paola Casule, Alberto Mariani, Mario SechiWith the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems.
History
Publication status
- Published
File Version
- Published version
Journal
ArkivocISSN
1551-7012Publisher
Michegan PublishingExternal DOI
Issue
9Volume
2011Page range
1-14Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-23First Open Access (FOA) Date
2015-07-23First Compliant Deposit (FCD) Date
2015-07-23Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC