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Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors

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posted on 2023-06-08, 21:49 authored by Mohamed F Y Gomaa, Nicolino Pala, Marco Derudas, Jehan Abd-Elrazik Hasanen, El-Sayed H El-Tamany, Paola Casule, Alberto Mariani, Mario Sechi
With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems.

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Publication status

  • Published

File Version

  • Published version

Journal

Arkivoc

ISSN

1551-7012

Publisher

Michegan Publishing

Issue

9

Volume

2011

Page range

1-14

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-07-23

First Open Access (FOA) Date

2015-07-23

First Compliant Deposit (FCD) Date

2015-07-23

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