elife-27333-v1.pdf (1.89 MB)
Learning and recognition of tactile temporal sequences by mice and humans
journal contribution
posted on 2023-06-08, 21:05 authored by Michael Bale, Malamati Bitzidou, Anna Pitas, Leonie Sophie Brebner, Lina Khazim, Stavros Anagnou, Caitlin Stevenson, Miguel Maravall RodriguezMiguel Maravall RodriguezThe world around us is replete with stimuli that unfold over time. When we hear an auditory stream like music or speech or scan a texture with our fingertip, physical features in the stimulus are concatenated in a particular order. This temporal patterning is critical to interpreting the stimulus. To explore the capacity of mice and humans to learn tactile sequences, we developed a task in which subjects had to recognise a continuous modulated noise sequence delivered to whiskers or fingertips, defined by its temporal patterning over hundreds of milliseconds. GO and NO-GO sequences differed only in that the order of their constituent noise modulation segments was temporally scrambled. Both mice and humans efficiently learned tactile sequences. Mouse sequence recognition depended on detecting transitions in noise amplitude; animals could base their decision on the earliest information available. Humans appeared to use additional cues, including the duration of noise modulation segments.
Funding
Sensory sequence representation and discrimination in cortical circuits; G1975; MRC-MEDICAL RESEARCH COUNCIL; MR/P006639/1
History
Publication status
- Published
File Version
- Published version
Journal
eLifeISSN
2050-084XPublisher
eLife Sciences PublicationsExternal DOI
Issue
6Volume
2017Article number
e27333Department affiliated with
- BSMS Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-08-17First Open Access (FOA) Date
2017-08-17First Compliant Deposit (FCD) Date
2017-08-17Usage metrics
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