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Converging evidence for central 5-HT effects in acute tryptophan depletion
journal contribution
posted on 2023-06-08, 19:28 authored by M J Crockett, L Clark, J P Roiser, O J Robinson, R Cools, H W Chase, H den Ouden, A Apergis-Schoute, Dan Campbell-MeiklejohnDan Campbell-Meiklejohn, B Seymour, B J Sahakian, R D Rogers, T W RobbinsAcute tryptophan depletion (ATD), a dietary technique for manipulating brain serotonin (5-HT) function, has advanced our understanding of 5-HT mechanisms in the etiology and treatment of depression and other affective disorders.1 A recent review article in Molecular Psychiatry questioned the validity of ATD.2 Although we agree that ATD's effects on 5-HT activity at the molecular level need further clarification, van Donkelaar et al.2 goes too far in challenging whether ATD exerts its effects through serotonergic mechanisms. There is strong evidence that ATD reduces brain 5-HT and disrupts stimulated 5-HT release,3, 4 and converging translational findings support a central role for brain 5-HT in ATD's effects on cognition and behavior.
History
Publication status
- Published
Journal
Molecular PsychiatryISSN
1359-4184Publisher
Nature Publishing GroupExternal DOI
Issue
2Volume
17Page range
121-123Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-02-11Usage metrics
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