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Role of nanocarrier systems in cancer nanotherapy

journal contribution
posted on 2023-06-08, 19:22 authored by M R Mozafari, A Pardakhty, S Azarmi, J A Jazayeri, Ali Nokhodchi, A Omri
Cancer continues to be a major cause of morbidity and mortality worldwide. While discovery of new drugs and cancer chemotherapy opened a new era for the treatment of tumors, optimized concentration of drug at the target site is only possible at the expense of severe side effects. Nanoscale carrier systems have the potential to limit drug toxicity and achieve tumor localization. When linked with tumor-targeting moieties, such as tumor-specific ligands or monoclonal antibodies, the nanocarriers can be used to target cancer-specific receptors, tumor antigens, and tumor vasculatures with high affinity and precision. This article is an overview of advances and prospects in the applications of nanocarrier technology in cancer therapy. Applications of nanoliposomes, dendrimers, and nanoparticles in cancer therapy are explained, along with their preparation methods and targeting strategies.

History

Publication status

  • Published

Journal

Journal of Liposome Research

ISSN

0898-2104

Publisher

Informa Healthcare

Issue

4

Volume

19

Page range

310-321

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-21

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    University of Sussex (Publications)

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