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Role of nanocarrier systems in cancer nanotherapy
journal contribution
posted on 2023-06-08, 19:22 authored by M R Mozafari, A Pardakhty, S Azarmi, J A Jazayeri, Ali Nokhodchi, A OmriCancer continues to be a major cause of morbidity and mortality worldwide. While discovery of new drugs and cancer chemotherapy opened a new era for the treatment of tumors, optimized concentration of drug at the target site is only possible at the expense of severe side effects. Nanoscale carrier systems have the potential to limit drug toxicity and achieve tumor localization. When linked with tumor-targeting moieties, such as tumor-specific ligands or monoclonal antibodies, the nanocarriers can be used to target cancer-specific receptors, tumor antigens, and tumor vasculatures with high affinity and precision. This article is an overview of advances and prospects in the applications of nanocarrier technology in cancer therapy. Applications of nanoliposomes, dendrimers, and nanoparticles in cancer therapy are explained, along with their preparation methods and targeting strategies.
History
Publication status
- Published
Journal
Journal of Liposome ResearchISSN
0898-2104Publisher
Informa HealthcareExternal DOI
Issue
4Volume
19Page range
310-321Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-12-21Usage metrics
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