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Solubility prediction of paracetamol in water-glycerol mixtures at 25 and 30 °c using the jouyban-acree model

journal contribution
posted on 2023-06-08, 19:22 authored by Abolghasem Jouyban, Mohammad A A Fakhree, Shahla Mirzaei, Taravat Ghafourian, Shahla Soltanpour, Ali Nokhodchi
The solubility of paracetamol in water-glycerol mixtures at 25 and 30 °C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and was also used to assess the prediction capability of a trained version of the Jouyban-Acree model for solubility prediction in water-glycerol mixtures at various temperatures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation between the predicted and experimental solubilities. The overall mean percentage deviation of the Jouyban-Acree model for the back-calculated solubility data from the literature was 37.9 ± 21.9%. The corresponding value for the predicted solubilities of paracetamol in binary mixtures using experimental values of paracetamol solubilities in water and glycerol was 15.6 ± 11.1%.

History

Publication status

  • Published

Journal

Asian Journal of Chemistry

ISSN

0970-7077

Publisher

Chemic Publishing Company

Issue

9

Volume

21

Page range

7249-7253

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-21

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